| Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors. | |
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MedLine Citation:
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PMID: 20934767 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been suggested to be a useful method for assessing the extent of hypoxia in tumors. In this study, we investigated whether differences in hypoxic fraction between tumors caused by the site of growth can be detected by DCE-MRI. MATERIALS AND METHODS: Intradermal and intramuscular A-07 tumors were subjected to DCE-MRI, histological analysis of microvascular characteristics, and measurement of hypoxic cell fractions using a radiobiological assay and a pimonidazole-based immunohistochemical assay. Parametric images of E·F (blood perfusion) and v(e) (extracellular volume fraction) were produced by pharmacokinetic analysis of the DCE-MRI series. RESULTS: The intramuscular tumors had 3-4-fold higher hypoxic fractions than the intradermal tumors, owing to a lower microvascular density. This difference in extent of hypoxia was not detectable in the parametric MR images. Most likely, larger vessel diameters compensated for the lower vessel density in the intramuscular tumors, resulting in E·F images that were similar to those of the intradermal tumors. CONCLUSION: Quantitative assessment of hypoxic fractions from parametric MR images may require tumor site-specific translational criteria. |
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Authors:
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Kristine Gulliksrud; Berit Mathiesen; Kanthi Galappathi; Einar K Rofstad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-09 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 97 ISSN: 1879-0887 ISO Abbreviation: Radiother Oncol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: Ireland |
Other Details:
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Languages: eng Pagination: 233-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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