Document Detail


Quantitative assessment of WT1 expression in diagnosis of childhood acute leukemia.
MedLine Citation:
PMID:  16876863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate WT1 expression levels in childhood acute leukemia. Bone marrow from 14 children with acute leukemia at diagnosis and from 7 children with solid tumors without bone marrow involvement (control group) was studied. Five of the 14 patients (35.7%), expressed high levels of WT1. Four of the five WT1 positive patients with additional adverse prognostic factors, have succumbed to their disease. The results of this study are in accordance with the fact that high levels of WT1 expression have been reported in patients with an unfavorable outcome.
Authors:
A Spanaki; E Linardakis; C Perdikogianni; E Stiakaki; A Morotti; D Cilloni; M Kalmanti
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Publication Detail:
Type:  Letter     Date:  2006-07-31
Journal Detail:
Title:  Leukemia research     Volume:  31     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-09     Completed Date:  2007-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  570-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Bone Marrow / pathology
Child
Child, Preschool
Female
Humans
Infant
Leukemia, Myeloid, Acute / diagnosis*,  genetics,  metabolism
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*,  genetics,  metabolism
WT1 Proteins / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/WT1 Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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