Document Detail

Quantitative assessment of Langerhans cells in actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma.
MedLine Citation:
PMID:  3763243     Owner:  NLM     Status:  MEDLINE    
The quantitative distribution of Langerhans cells (LC) was studied in a range of pre-neoplastic, in-situ and invasive neoplastic skin lesions using an antibody to S100 protein and the indirect immunoperoxidase technique. LC numbers were increased within the lesions of actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma. In all lesions except actinic keratosis the LC density was also significantly increased in the adjacent non-neoplastic epithelium. The increased LC density in neoplastic epithelium suggests either that LC are being retained within the abnormal epithelium for longer periods of time than normal or that increased numbers of LC are being actively attracted by factors produced by the neoplastic epithelium. While reduction of intraepithelial LC density may allow the initiation of neoplasia the increased density observed in this study suggests that at later stages of tumour growth LC may have a functional role in the host response to cutaneous neoplasia.
J P McArdle; B A Knight; G M Halliday; H K Muller; G Rowden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology     Volume:  18     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-11-13     Completed Date:  1986-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
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MeSH Terms
Bowen's Disease / pathology*
Carcinoma, Basal Cell / pathology*
Carcinoma, Squamous Cell / pathology*
Keratoacanthoma / pathology*
Keratosis / pathology*
Langerhans Cells / cytology*
Skin / cytology,  pathology
Skin Diseases / pathology*
Skin Neoplasms / pathology*

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