Document Detail

Quantitative aspects of synaptic ribbon formation in the outer plexiform layer of the developing cat retina.
MedLine Citation:
PMID:  2487088     Owner:  NLM     Status:  MEDLINE    
The development of synaptic ribbons in rod and cone photoreceptor terminals of the cat retina was studied using quantitative electron microscopy. At the region of the area centralis, synaptic ribbon profiles are initially recognized at PCD (postconception day) 59. Synaptic ribbon density increases rapidly, reaching a peak of 0.55 ribbons/micron 3 at PCD 68 (postnatal day 3) and maintains approximately that value for an additional 8 d. Following PCD 76, ribbon density begins to decrease, to 0.37 ribbons/microns 3 at PCD 82 and 0.25 ribbons/microns 3 at PCD 102. Although ribbon density drops by approximately 50% during this 39-d period, the outer plexiform layer (OPL) volume at the area centralis increases by about 20%. Ribbon density continues to decrease gradually over a protracted period to reach a final adult value of 0.11-0.14 ribbons/microns 3. During the period of high ribbon density, rod spherules with two, or even three ribbon profiles, were routinely observed. In contrast, in the adult, spherules with more than one ribbon profile are only rarely encountered. During development, the length of synaptic ribbon profiles increases from a mean of 0.22 microns at PCD 62 to the 0.47 microns mean length found in the adult.
D H Rapaport
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Visual neuroscience     Volume:  3     ISSN:  0952-5238     ISO Abbreviation:  Vis. Neurosci.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1991-03-13     Completed Date:  1991-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809466     Medline TA:  Vis Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-32     Citation Subset:  IM    
School of Anatomy, University of New South Wales, Sydney, Australia.
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MeSH Terms
Cell Count
Retina / embryology,  growth & development,  ultrastructure*
Synapses / ultrastructure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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