Document Detail


Quantitative aspects of perinatal lung growth.
MedLine Citation:
PMID:  3622349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Weight, DNA, protein, hydroxyproline and disaturated phosphatidylcholine (DSPC) content were investigated in lungs of 97 normally formed infants over an age range from 22 to 75 postconceptional weeks, including 25 cases of hyaline membrane disease (HMD) and 13 small-for-dates infants (SFD). Lung weight and lung DNA relative to body weight were markedly lower in infants who died at 37-41 weeks than in those who died at shorter gestations or in early infancy. Total lung DSPC and DSPC concentration had a narrow peak at 36-41 weeks. The DSPC concentration per milligram of lung DNA in the first few months of infant life was similar to that in infants at 24 weeks gestation. Lung protein concentrations increased steadily but were variable at all ages. SFD infants had significantly higher concentrations of hydroxyproline and showed a peak DSPC concentration at an earlier gestation than the normals. Lungs of HMD infants showed some increase in hydroxyproline concentration but little other quantitative evidence of difference from the normals. We suggest that the relatively small lung size in many infants who die near term may result from recurrent intrauterine stress. Lung changes in small for dates infants are compatible with an advance in lung maturation, while the increased hydroxyproline concentration in the lungs of cases of HMD implies an early proliferative response to lung injury.
Authors:
J S Wigglesworth; R Desai; V Aber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  15     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-30     Completed Date:  1987-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA / metabolism
Embryonic and Fetal Development
Gestational Age
Humans
Hyaline Membrane Disease / metabolism
Hydroxyproline / metabolism
Infant
Infant, Newborn / growth & development*,  metabolism
Lung / anatomy & histology,  growth & development*,  metabolism
Organ Size
Proteins / metabolism
Pulmonary Surfactants / metabolism
Chemical
Reg. No./Substance:
0/Proteins; 0/Pulmonary Surfactants; 51-35-4/Hydroxyproline; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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