| Quantitative aspects of the intestinal absorption and metabolism of cholesterol and beta-sitosterol in the rat. | |
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MedLine Citation:
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PMID: 5725879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The quantitative aspects of intestinal absorption and metabolism of cholesterol and -sitosterol have been studied in the rat after a single feeding of radioactive sterols. When increasing amounts of cholesterol were fed in a constant amount of triolein, the percentage absorbed decreased only gradually and the total amounts absorbed increased to a maximum. Solubility in the fat component fed is one limiting factor in the absorption of cholesterol. At the lowest dose fed, only about 50% of dietary cholesterol was absorbed even though increasing the amount fed led to a 10- to 15-fold increase in total absorption. Sitosterol, when fed in triolein, was absorbed in amounts only one-tenth of the corresponding dose of cholesterol. Intestinal transit studies indicate that the distinction between sitosterol and cholesterol, when fed together, took place during the process of uptake into the intestinal mucosa. Once taken up by the intestinal mucosal cells, cholesterol and sitosterol did not differ in their subsequent rate of transit out of the mucosal cell. Feeding sitosterol with cholesterol seems to have the same effect on cholesterol absorption as feeding the same additional dose of cholesterol, the difference being that sitosterol is taken up by the intestinal wall in amounts only one-tenth to one-fifth of that of cholesterol. The rapid and complete absorption of the triglyceride fat and the subsequent transit of the intestinal content to the large intestine are most probably important factors in the determination of the extent of absorption of nonglyceride fat. The mechanism behind the difference in extent of absorption of the closely related sterols is not explained. |
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Authors:
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B Borgström |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 9 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1968 Jul |
Date Detail:
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Created Date: 1969-02-04 Completed Date: 1969-02-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 473-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Carbon Isotopes Cholesterol / metabolism* Feces / analysis Intestinal Absorption* Intestinal Mucosa / metabolism Intestine, Large / metabolism Intestine, Small / metabolism Liver / metabolism Male Oleic Acids Rats Sterols / metabolism* Time Factors Triolein Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Oleic Acids; 0/Sterols; 10028-17-8/Tritium; 122-32-7/Triolein; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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