Document Detail


Quantitative analysis of skeletal muscle bioenergetics and proton efflux in migraine and cluster headache.
MedLine Citation:
PMID:  9077499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phosphorus MR spectroscopy (31P-MRS) was used to quantify skeletal muscle bioenergetics and proton efflux in 63 patients with migraine (23 with migraine without aura, MwoA, 22 with migraine with aura, MwA, and 18 with prolonged aura or stroke, CM) and in 14 patients with cluster headache (CH), all in an attack-free period. At rest mitochondrial function was abnormal only in CM, as shown by a low phosphocreatine (PCr) concentration. At the end of a mixed glycolytic/aerobic exercise all three migraine groups showed a significantly smaller decrease of cytosolic pH compared to controls with a similar end-exercise PCr breakdown, while end-exercise pH was normal in cluster headache patients. The normal rate of proton efflux in all headache groups suggests that the reduced end-exercise acidification was due to a reduction of glycolytic flux in migraine patients. The maximum rate of mitochondrial ATP production (Qmax), calculated from the rate of post-exercise PCr recovery and the end-exercise [ADP], was low in cluster headache patients as well as in migraine patients except MwoA. In migraine the degree of the mitochondrial impairment, that apparently is associated with a reduced glycolytic flux, is related to the severity of the clinical phenotype.
Authors:
R Lodi; G J Kemp; P Montagna; G Pierangeli; P Cortelli; S Iotti; G K Radda; B Barbiroli
Related Documents :
17218429 - Effects of hyperventilation on phosphocreatine kinetics and muscle deoxygenation during...
20533099 - Blood uridine concentration may be an indicator of the degradation of pyrimidine nucleo...
15052619 - Attenuation of free radical production and paracrystalline inclusions by creatine suppl...
1827789 - Abnormal high-energy phosphate metabolism in human muscle phosphofructokinase deficiency.
11744769 - The role of phosphorylcreatine and creatine in the regulation of mitochondrial respirat...
8814419 - Phosphorus magnetic resonance spectroscopy in the evaluation of mitochondrial myopathie...
18368409 - Evaluation of knee proprioception and effects of proprioception exercise in patients wi...
15994239 - No effect of short-term testosterone manipulation on exercise substrate metabolism in men.
23406699 - Lower head temperature does not affect children's self-paced running velocity.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  146     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Affiliation:
Dipartimento di Medicina Clinica e Biotecnologia Applicata D. Campanacci, Universita di Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Case-Control Studies
Cluster Headache / metabolism*,  pathology
Energy Metabolism / physiology*
Exercise / physiology
Glycolysis / physiology
Humans
Linear Models
Magnetic Resonance Spectroscopy / methods
Middle Aged
Migraine Disorders / metabolism*,  pathology
Mitochondria, Muscle / pathology*
Muscle, Skeletal / metabolism*
Protons
Chemical
Reg. No./Substance:
0/Protons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A collaborative study on the natural history of childhood and juvenile onset proximal spinal muscula...
Next Document:  Sporadic adult-onset distal myopathy with rimmed vacuoles, 15-18 nm tubulofilaments and extensive ro...