Document Detail

Quantitative analysis of skeletal muscle bioenergetics and proton efflux in migraine and cluster headache.
MedLine Citation:
PMID:  9077499     Owner:  NLM     Status:  MEDLINE    
Phosphorus MR spectroscopy (31P-MRS) was used to quantify skeletal muscle bioenergetics and proton efflux in 63 patients with migraine (23 with migraine without aura, MwoA, 22 with migraine with aura, MwA, and 18 with prolonged aura or stroke, CM) and in 14 patients with cluster headache (CH), all in an attack-free period. At rest mitochondrial function was abnormal only in CM, as shown by a low phosphocreatine (PCr) concentration. At the end of a mixed glycolytic/aerobic exercise all three migraine groups showed a significantly smaller decrease of cytosolic pH compared to controls with a similar end-exercise PCr breakdown, while end-exercise pH was normal in cluster headache patients. The normal rate of proton efflux in all headache groups suggests that the reduced end-exercise acidification was due to a reduction of glycolytic flux in migraine patients. The maximum rate of mitochondrial ATP production (Qmax), calculated from the rate of post-exercise PCr recovery and the end-exercise [ADP], was low in cluster headache patients as well as in migraine patients except MwoA. In migraine the degree of the mitochondrial impairment, that apparently is associated with a reduced glycolytic flux, is related to the severity of the clinical phenotype.
R Lodi; G J Kemp; P Montagna; G Pierangeli; P Cortelli; S Iotti; G K Radda; B Barbiroli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  146     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Dipartimento di Medicina Clinica e Biotecnologia Applicata D. Campanacci, Universita di Bologna, Italy.
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MeSH Terms
Case-Control Studies
Cluster Headache / metabolism*,  pathology
Energy Metabolism / physiology*
Exercise / physiology
Glycolysis / physiology
Linear Models
Magnetic Resonance Spectroscopy / methods
Middle Aged
Migraine Disorders / metabolism*,  pathology
Mitochondria, Muscle / pathology*
Muscle, Skeletal / metabolism*
Reg. No./Substance:

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