Document Detail


Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals.
MedLine Citation:
PMID:  21363871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple studies suggest that the corpus callosum in patients with autism is reduced in size. This study attempts to elucidate the nature of this morphometric abnormality by analyzing the shape of this structure in 17 high-functioning patients with autism and an equal number of comparison participants matched for age, sex, IQ, and handedness. The corpus callosum was segmented from T1 weighted images acquired with a Siemens 1.5 T scanner. Transformed coordinates of the curvilinear axis were aggregated into a parametric map and compared across series to derive regions of statistical significance. Our results indicate that a reduction in size of the corpus callosum occurs over all of its subdivisions (genu, body, splenium) in patients with autism. Since the commissural fibers that traverse the different anatomical compartments of the corpus callosum originate in disparate brain regions our results suggest the presence of widely distributed cortical abnormalities in people with autism.
Authors:
Manuel F Casanova; Ayman El-Baz; Ahmed Elnakib; Andrew E Switala; Emily L Williams; Diane L Williams; Nancy J Minshew; Thomas E Conturo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-01
Journal Detail:
Title:  Autism : the international journal of research and practice     Volume:  15     ISSN:  1461-7005     ISO Abbreviation:  Autism     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-08-16     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9713494     Medline TA:  Autism     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Agenesis of Corpus Callosum
Autistic Disorder / pathology*
Brain Mapping
Case-Control Studies
Corpus Callosum / anatomy & histology,  pathology*
Female
Functional Laterality
Humans
Intelligence Tests
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Young Adult
Grant Support
ID/Acronym/Agency:
ACE P50 HD55748/HD/NICHD NIH HHS; CPEA U19 HD35469/HD/NICHD NIH HHS; K23 DC06691/DC/NIDCD NIH HHS; P50 HD055748/HD/NICHD NIH HHS; P50 HD055748-01/HD/NICHD NIH HHS; P50 HD055748-02/HD/NICHD NIH HHS; P50 HD055748-03/HD/NICHD NIH HHS; P50 HD055748-03S1/HD/NICHD NIH HHS; P50 HD055748-04/HD/NICHD NIH HHS; P50 HD055748-05/HD/NICHD NIH HHS; R01 HD65279/HD/NICHD NIH HHS; R01 MH086784/MH/NIMH NIH HHS; R01 MH086784-01/MH/NIMH NIH HHS; R01 MH086784-02/MH/NIMH NIH HHS; R01 MH086784-03/MH/NIMH NIH HHS; R01 MH086784-04/MH/NIMH NIH HHS; R01 MH86784/MH/NIMH NIH HHS; R01 NS039538-01A1/NS/NINDS NIH HHS; R01 NS039538-02/NS/NINDS NIH HHS; R01 NS039538-03/NS/NINDS NIH HHS; R01 NS039538-04/NS/NINDS NIH HHS; R01 NS039538-05/NS/NINDS NIH HHS; R01 NS052470/NS/NINDS NIH HHS; R01 NS052470-01A2/NS/NINDS NIH HHS; R01 NS052470-02/NS/NINDS NIH HHS; R01 NS052470-03/NS/NINDS NIH HHS; R01 NS052470-04/NS/NINDS NIH HHS; R01 NS052470-05/NS/NINDS NIH HHS; R01 NS39538/NS/NINDS NIH HHS; R01 NS52470/NS/NINDS NIH HHS; R21 MH90494/MH/NIMH NIH HHS
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