| Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals. | |
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MedLine Citation:
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PMID: 21363871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple studies suggest that the corpus callosum in patients with autism is reduced in size. This study attempts to elucidate the nature of this morphometric abnormality by analyzing the shape of this structure in 17 high-functioning patients with autism and an equal number of comparison participants matched for age, sex, IQ, and handedness. The corpus callosum was segmented from T1 weighted images acquired with a Siemens 1.5 T scanner. Transformed coordinates of the curvilinear axis were aggregated into a parametric map and compared across series to derive regions of statistical significance. Our results indicate that a reduction in size of the corpus callosum occurs over all of its subdivisions (genu, body, splenium) in patients with autism. Since the commissural fibers that traverse the different anatomical compartments of the corpus callosum originate in disparate brain regions our results suggest the presence of widely distributed cortical abnormalities in people with autism. |
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Authors:
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Manuel F Casanova; Ayman El-Baz; Ahmed Elnakib; Andrew E Switala; Emily L Williams; Diane L Williams; Nancy J Minshew; Thomas E Conturo |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-01 |
Journal Detail:
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Title: Autism : the international journal of research and practice Volume: 15 ISSN: 1461-7005 ISO Abbreviation: Autism Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-13 Completed Date: 2011-08-16 Revised Date: 2013-05-26 |
Medline Journal Info:
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Nlm Unique ID: 9713494 Medline TA: Autism Country: England |
Other Details:
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Languages: eng Pagination: 223-38 Citation Subset: IM |
Affiliation:
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University of Louisville, Kentucky, USA. m0casa02@louisville.edu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agenesis of Corpus Callosum Autistic Disorder / pathology* Brain Mapping Case-Control Studies Corpus Callosum / anatomy & histology, pathology* Female Functional Laterality Humans Intelligence Tests Magnetic Resonance Imaging Male Middle Aged Organ Size Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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ACE P50 HD55748/HD/NICHD NIH HHS; CPEA U19 HD35469/HD/NICHD NIH HHS; K23 DC06691/DC/NIDCD NIH HHS; P50 HD055748-01/HD/NICHD NIH HHS; P50 HD055748-02/HD/NICHD NIH HHS; P50 HD055748-03/HD/NICHD NIH HHS; P50 HD055748-03S1/HD/NICHD NIH HHS; P50 HD055748-04/HD/NICHD NIH HHS; P50 HD055748-05/HD/NICHD NIH HHS; R01 HD65279/HD/NICHD NIH HHS; R01 MH086784-01/MH/NIMH NIH HHS; R01 MH086784-02/MH/NIMH NIH HHS; R01 MH086784-03/MH/NIMH NIH HHS; R01 MH086784-04/MH/NIMH NIH HHS; R01 MH86784/MH/NIMH NIH HHS; R01 NS039538-01A1/NS/NINDS NIH HHS; R01 NS039538-02/NS/NINDS NIH HHS; R01 NS039538-03/NS/NINDS NIH HHS; R01 NS039538-04/NS/NINDS NIH HHS; R01 NS039538-05/NS/NINDS NIH HHS; R01 NS052470-01A2/NS/NINDS NIH HHS; R01 NS052470-02/NS/NINDS NIH HHS; R01 NS052470-03/NS/NINDS NIH HHS; R01 NS052470-04/NS/NINDS NIH HHS; R01 NS052470-05/NS/NINDS NIH HHS; R01 NS39538/NS/NINDS NIH HHS; R01 NS52470/NS/NINDS NIH HHS; R21 MH90494/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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