| Quantitative analysis of proliferation and cell cycle length during development of the rat retina. | |
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MedLine Citation:
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PMID: 8850565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rat retina has been a useful model system for the study of the development of the central nervous system (CNS). In order to facilitate future studies on the mechanisms that control retinal growth, we have quantified the proliferation of retinal cells and the length of the cell cycle throughout development. For each day during development, the number of mitotic and postmitotic cells per retina, the proportion of cycling cells, S phase length, and cell cycle length were determined through quantification of cell numbers and 3H-thymidine labeling. As retinal development proceeds, the proportion of cycling cells decreases, and cell cycle length increases, in part due to an increase in S phase length. |
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Authors:
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M R Alexiades; C Cepko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 205 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-06 Completed Date: 1996-12-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 293-307 Citation Subset: IM |
Affiliation:
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Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bromodeoxyuridine / pharmacology Cell Count Cell Cycle Cell Division DNA Isotope Labeling Mitosis Rats Rats, Sprague-Dawley Retina / cytology*, embryology, growth & development* S Phase Time Factors |
| Chemical | |
Reg. No./Substance:
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59-14-3/Bromodeoxyuridine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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