| Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. | |
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MedLine Citation:
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PMID: 8033339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The expression of 15 different potassium channel genes in rat atrial and ventricular muscle was quantitatively compared by use of an RNase protection assay. Of these genes, only five, Kv1.2, Kv1.4, Kv1.5, Kv2.1, and Kv4.2, were expressed at significant levels in cardiac muscle. In comparisons of atrial and ventricular RNA samples, transcripts from the Kv1.2 and Kv4.2 genes showed the largest differences in relative abundance. There was an approximately twofold decrease in total Kv4 subfamily mRNA expression in atrial muscle relative to ventricular muscle and a 70% increase in total Kv1 subfamily mRNA. Variation of potassium channel mRNA expression within the left ventricular wall was also examined. There was a large gradient of Kv4.2 expression across the ventricular wall, and Kv4.2 expression in epicardial muscle was more than eight times higher than in papillary muscle. Other potassium channel genes were expressed at relatively uniform levels across the ventricular wall. The results suggest that transcriptional regulation makes a significant contribution to the control of potassium channel expression in cardiac muscle and to the variation of the electrophysiological phenotype of myocytes from different regions of the myocardium. |
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Authors:
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J E Dixon; D McKinnon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation research Volume: 75 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-08-18 Completed Date: 1994-08-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 252-60 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Behavior, State University of New York at Stony Brook 11794-5230. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Female Gene Expression Heart Atria Heart Conduction System / cytology, metabolism Heart Ventricles Molecular Sequence Data Myocardium / metabolism* Neurons / metabolism Parasympathetic Nervous System / cytology, metabolism Potassium Channels / genetics*, metabolism RNA, Messenger / metabolism* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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NS-29755/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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