Document Detail


Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human.
MedLine Citation:
PMID:  12781996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of a rodent model in the perinatal rat or mouse that reproduces the principal features of human perinatal white matter injury (periventricular leukomalacia) has been hampered by uncertainty about the developmental window in the rodent that coincides temporally with cerebral white matter development in the premature infant. We recently determined oligodendrocyte (OL) lineage progression in human cerebral white matter and found that the late OL progenitor (preOL) predominates throughout the high-risk period for periventricular leukomalacia [J. Neurosci. 21(2001), 1302-1312]. Here, we determined in the perinatal rat and mouse when each species displays a distribution of OL stages that is similar to the premature human cerebral white matter. PreOLs are abundant in the rat and mouse at P2. By P7, extensive OL maturation occurs in both species and coincides with the onset of early myelination. PreOLs and immature OLs mature in the P2 white matter along a medial to lateral gradient. This may provide an explanation for regional variation in the susceptibility of perinatal white matter to injury. We propose that the sequence of OL lineage progression is a useful means to estimate developmental windows of white matter maturation in perinatal rodents that coincide with those of developing human cerebral white matter. These studies support that the vulnerable period for white matter injury in the rodent is centered around P2 and should decline thereafter, coincident with the onset of myelination.
Authors:
Andrew Craig; Ning Ling Luo; Douglas J Beardsley; Nasiema Wingate-Pearse; David W Walker; A Roger Hohimer; Stephen A Back
Related Documents :
11153896 - Cerebral palsy and experimental hypoxia-induced perinatal brain injury: is magnesium pr...
18089296 - Foetal growth determines cerebral ventricular volume in infants the generation r study.
24438416 - Potentially avoidable neonatal retrievals in new south wales: a retrospective analysis.
2071366 - Correlation between clinical and ultrasound findings in preterm infants with cystic per...
3756256 - Regional variations of iodine nutrition and thyroid function during the neonatal period...
16712596 - Management of infants and young children with combined heart and kidney failure.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  181     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2003-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-40     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Oregon Health and Science University, Portland 97201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / cytology*,  growth & development,  metabolism
Cell Count
Cell Differentiation / physiology*
Cell Lineage / physiology
Fluorescent Antibody Technique
Humans
Immunohistochemistry
Mice
Mice, Inbred C57BL
Myelin Sheath / metabolism
Oligodendroglia / cytology*,  metabolism
Rats
Rats, Sprague-Dawley
Species Specificity
Stem Cells / cytology*,  metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
HD 33703/HD/NICHD NIH HHS; NS41343/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus.
Next Document:  Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF...