Document Detail

Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure.
MedLine Citation:
PMID:  7808266     Owner:  NLM     Status:  MEDLINE    
Quantitative analysis of Gd-DTPA enhanced dynamic MR images has potential for discriminating lesions, especially because the introduction of clinical fast imaging techniques has enabled good sampling of the relatively rapid Gd-DTPA wash-in curves. Analysis of such data requires curve fitting to a nonlinear model, which to date has been performed using a nonlinear least squares (NLLS) fitting procedure. However, this method often fails to converge to the appropriate minima without good initial parameter estimates when multi-exponential models are involved, making automated analysis of complete multislice or volume data sets problematic. In this report we demonstrate the robust performance of a simplex minimization procedure compared with NLLS, by the method of Marquardt, using a Monte Carlo simulation. Further, we illustrate the applicability of such a technique to the analysis of dynamic contrast enhanced images on a pixel-by-pixel basis. As a preliminary example, the technique is applied to a breast lesion but is expected to be suitable for examination of many lesion types.
D L Buckley; R W Kerslake; S J Blackband; A Horsman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  32     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-02-02     Completed Date:  1995-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  646-51     Citation Subset:  IM    
Centre for MR Investigations, Hull Royal Infirmary, United Kingdom.
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MeSH Terms
Breast Neoplasms / pathology
Carcinoma, Ductal, Breast / pathology
Computer Simulation
Contrast Media*
Gadolinium / diagnostic use*
Gadolinium DTPA
Image Enhancement / methods*
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / instrumentation,  methods*
Models, Theoretical*
Monte Carlo Method
Neoplasm Invasiveness
Organometallic Compounds / diagnostic use*
Pentetic Acid / analogs & derivatives*,  diagnostic use
Signal Processing, Computer-Assisted
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA
Erratum In:
Magn Reson Med 1995 Feb;33(2):282

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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