| Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure. | |
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MedLine Citation:
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PMID: 7808266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quantitative analysis of Gd-DTPA enhanced dynamic MR images has potential for discriminating lesions, especially because the introduction of clinical fast imaging techniques has enabled good sampling of the relatively rapid Gd-DTPA wash-in curves. Analysis of such data requires curve fitting to a nonlinear model, which to date has been performed using a nonlinear least squares (NLLS) fitting procedure. However, this method often fails to converge to the appropriate minima without good initial parameter estimates when multi-exponential models are involved, making automated analysis of complete multislice or volume data sets problematic. In this report we demonstrate the robust performance of a simplex minimization procedure compared with NLLS, by the method of Marquardt, using a Monte Carlo simulation. Further, we illustrate the applicability of such a technique to the analysis of dynamic contrast enhanced images on a pixel-by-pixel basis. As a preliminary example, the technique is applied to a breast lesion but is expected to be suitable for examination of many lesion types. |
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Authors:
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D L Buckley; R W Kerslake; S J Blackband; A Horsman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 32 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-02-02 Completed Date: 1995-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 646-51 Citation Subset: IM |
Affiliation:
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Centre for MR Investigations, Hull Royal Infirmary, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Breast Neoplasms / pathology Carcinoma, Ductal, Breast / pathology Computer Simulation Contrast Media* Female Gadolinium / diagnostic use* Gadolinium DTPA Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / instrumentation, methods* Models, Theoretical* Monte Carlo Method Neoplasm Invasiveness Organometallic Compounds / diagnostic use* Pentetic Acid / analogs & derivatives*, diagnostic use Signal Processing, Computer-Assisted |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
Erratum In:
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Magn Reson Med 1995 Feb;33(2):282 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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