| Quantitative analysis of the microcirculation of xenogeneic haemoperfused rat livers by intravital microscopy. | |
| | |
MedLine Citation:
|
PMID: 8959801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Livers from male Sprague-Dawley rats were perfused with heparinised, unmodified isogeneic rat blood (n = 6) or xenogeneic human blood. The microcirculation of these livers, as the primary manifestation of hyperacute xenogeneic rejection, was directly observed and quantified by using fluorescence videomicroscopy. Bile flow and enzyme release of the isogeneic perfused livers were in the physiological range, whereas bile flow was significantly reduced and enzyme release increased during xenogeneic perfusion. In contrast to an almost physiological acinar (90.4%) and sinusoidal (93.6%) perfusion rate in the isogeneic group, a rapid breakdown of microcirculation with an acinar perfusion index of 47.5% and a sinusoidal perfusion rate of 67.1% were found in the xenogeneic group. This direct quantification of microcirculatory parameters is a step forward towards sensitive and early characterisation of the severity of the xenogeneic rejection of the liver. |
| | |
Authors:
|
D Seehofer; H Baatz; J Thiery; C Hammer |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 9 Suppl 1 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 1996 |
Date Detail:
|
Created Date: 1997-03-12 Completed Date: 1997-03-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: GERMANY |
Other Details:
|
Languages: eng Pagination: S97-9 Citation Subset: IM |
Affiliation:
|
Institute for Surgical Research, Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Hemoperfusion* Humans Liver Circulation* Liver Transplantation* Male Microcirculation Microscopy Rats Rats, Sprague-Dawley |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of enalapril on microvascular perfusion and leukocyte adherence in a model of rat liver trans...
Next Document: Beneficial effects of prostaglandin E1 on hemodynamic changes during liver transplantation in pigs.