Document Detail

Quantitative analysis of lung perfusion in patients with primary pulmonary hypertension.
MedLine Citation:
PMID:  12050319     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate quantitatively the heterogeneity of lung perfusion scans in patients with primary pulmonary hypertension (PPH) and to compare it with the severity of disease. METHODS: Lung perfusion scans were obtained on 22 patients with PPH and 12 age-matched control subjects. The perfused area rates (PARs) were calculated by dividing the lung area in each 10% threshold width from 10% to 100% of maximal counts by total lung area. The total absolute difference in the PAR between each patient and the mean control value was assumed as the perfusion index of the lung (P index). The P index was compared with hemodynamic parameters and the right ventricular ejection fraction (RVEF), including 7 patients who received long-term vasodilator therapy. RESULTS: The P index correlated significantly with mean pulmonary arterial pressure (P < 0.001) and RVEF (P < 0.05). In patients with vasodilator therapy, the P index was improved significantly after therapy (P < 0.05) and was associated with a reduction in pulmonary arterial pressure. CONCLUSION: Quantitative assessment of lung perfusion irregularity might provide useful information about the severity of disease and the effect of therapy in addition to the routine visual representation.
Kazuki Fukuchi; Kohei Hayashida; Norifumi Nakanishi; Masayuki Inubushi; Shingo Kyotani; Noritoshi Nagaya; Yoshio Ishida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  43     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  757-61     Citation Subset:  IM    
Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Case-Control Studies
Hypertension, Pulmonary / physiopathology,  radionuclide imaging*
Lung / radionuclide imaging*
Pulmonary Circulation / physiology
Radiopharmaceuticals / diagnostic use*
Stroke Volume
Technetium Tc 99m Aggregated Albumin / diagnostic use*
Ventricular Function, Right
Ventriculography, First-Pass
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Aggregated Albumin

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