Document Detail


Quantitative analysis of long-term potentiation in the hippocampal dentate gyrus of the freely-moving 15-day-old rat.
MedLine Citation:
PMID:  7697387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The magnitude and duration of long-term potentiation (LTP) of perforant path/dentate granule cell synapses was examined in freely moving rats beginning at 15 days of age. Measures of dentate granule cell population EPSP slope and population spike amplitude (PSA) obtained before and after tetanization were used to evaluate the level of LTP. Tetanization resulted in significant enhancement of both the population EPSP slope (approximately +75%) and PSA (approximately +40%) measures. This enhancement was maintained without significant change for 18 h, after which both measures began a steady and continuous rise. Daily input/output response measures from age-matched nontetanized animals were used to factor out enhancement related to normal development. Under this schema, tetanization-induced enhancement of both EPSP slope and PSA measures decayed slowly, beginning 18-24 h after tetanization, returning to baseline 5 days after tetanization. Enhancement obtained from 90-day-old animals decayed to baseline 24 h after tetanization. The longer duration of LTP obtained from preweanlings is discussed with regard to the development of inhibitory systems modulating granule cell excitability.
Authors:
J D Bronzino; K Abu-Hasaballah; R J Austin-LaFrance; P J Morgane
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  36     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-03     Completed Date:  1995-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Affiliation:
Trinity College, Department of Engineering and Computer Science, Hartford, CT 06106.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Suckling
Electric Stimulation
Hippocampus / physiology*
Long-Term Potentiation*
Male
Movement / physiology
Rats
Rats, Sprague-Dawley
Tetany / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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