| Quantitative analysis of long-term potentiation in the hippocampal dentate gyrus of the freely-moving 15-day-old rat. | |
| | |
MedLine Citation:
|
PMID: 7697387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The magnitude and duration of long-term potentiation (LTP) of perforant path/dentate granule cell synapses was examined in freely moving rats beginning at 15 days of age. Measures of dentate granule cell population EPSP slope and population spike amplitude (PSA) obtained before and after tetanization were used to evaluate the level of LTP. Tetanization resulted in significant enhancement of both the population EPSP slope (approximately +75%) and PSA (approximately +40%) measures. This enhancement was maintained without significant change for 18 h, after which both measures began a steady and continuous rise. Daily input/output response measures from age-matched nontetanized animals were used to factor out enhancement related to normal development. Under this schema, tetanization-induced enhancement of both EPSP slope and PSA measures decayed slowly, beginning 18-24 h after tetanization, returning to baseline 5 days after tetanization. Enhancement obtained from 90-day-old animals decayed to baseline 24 h after tetanization. The longer duration of LTP obtained from preweanlings is discussed with regard to the development of inhibitory systems modulating granule cell excitability. |
| | |
Authors:
|
J D Bronzino; K Abu-Hasaballah; R J Austin-LaFrance; P J Morgane |
Related Documents
:
|
10232437 - Exercise training does not alter acetylcholine-induced responses in isolated pulmonary ... 10421227 - Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training. 23715407 - Whole-body vibration exercise training reduces arterial stiffness in postmenopausal wom... 15450527 - Dose-response relationship for exercise on severity of experimental osteoarthritis in r... 16672837 - Low-intensity exercise training improves survival in dahl salt hypertension. 3596877 - Impaired left ventricular diastolic function in athletes after utterly strenuous prolon... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Brain research bulletin Volume: 36 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-05-03 Completed Date: 1995-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 321-4 Citation Subset: IM |
Affiliation:
|
Trinity College, Department of Engineering and Computer Science, Hartford, CT 06106. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Suckling Electric Stimulation Hippocampus / physiology* Long-Term Potentiation* Male Movement / physiology Rats Rats, Sprague-Dawley Tetany / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estradiol enhances brain glucose uptake in ovariectomized rats.
Next Document: Power at local level.