Document Detail

Quantitative analysis of liver function in percutaneous transhepatic biliary drainage patients.
MedLine Citation:
PMID:  4039239     Owner:  NLM     Status:  MEDLINE    
The diagnostic usefulness of Tc-99m DISIDA cholescintigraphy as a predictor of eventual catheter and hepatic function in patients who have undergone percutaneous transhepatic biliary drainage (PTBD) for extrahepatic biliary obstruction was evaluated. Twenty-nine cholescintigrams were performed in 14 patients. The examinations were divided into two groups: Group A (N = 17), in which the patient's clinical status deteriorated within two to three days post-PTBD, and Group B (N = 12), in which the patients did well clinically post-PTBD. No significant difference between the two groups was demonstrated by visual analysis of the analog images or by analysis of serum bilirubin levels. A computer program, developed by the authors, quantitates several parameters of DISIDA kinetics, reflecting hepatic function based upon compartmental analysis. A significant difference (P less than .001) was demonstrated between the mean transport constants (blood clearance constant = k1; hepatic clearance constant = k2) for the two groups. It is concluded that serum bilirubin levels and visual inspection of analog images are inadequate independent predictors of hepatic function in patients post PTBD. The transport constants k1 and k2 are quantitative parameters of hepatic function that may be of prognostic value in patients post PTBD.
M G Velchik; W Schwartz; J W London; P T Makler; A Alavi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  10     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
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MeSH Terms
Catheterization / adverse effects
Cholestasis, Extrahepatic / surgery*
Drainage / methods*
Imino Acids / diagnostic use
Liver / physiopathology,  radionuclide imaging*
Middle Aged
Postoperative Complications / physiopathology
Technetium / diagnostic use
Technetium Tc 99m Disofenin
Reg. No./Substance:
0/Imino Acids; 0/Technetium Tc 99m Disofenin; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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