| Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection. | |
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MedLine Citation:
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PMID: 22365501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exogenous administration of IGF-1 has been proposed as a therapy for disc degeneration. The objectives of this study were to develop a numerical model for quantitatively analysing exogenous administration of IGF-1 into the intervertebral disc (IVD) via intradiscal injection and to investigate the effects of IGF-1 administration on distribution of glucose and oxygen in the IVD. In this study, the reversible binding reaction between IGF-1 and IGF binding proteins was incorporated into the mechano-electrochemical mixture model. The model was used to numerically analyse transport of IGF-1, glucose, oxygen and lactate in the IVD after IGF-1 administration. The enhancement of IGF-1 on lactate production was also taken into account in the theoretical model. The numerical analyses using finite element method demonstrated that the binding reactions significantly affect the time-dependent distribution of IGF-1 in the IVD. It was found that the region affected by IGF-1 was smaller and the duration of the therapeutic IGF-1 level was longer in the degenerated disc with a higher concentration of IGF binding proteins. It was also found that the IGF-1 injection can reduce glucose concentration and increase lactate accumulation (i.e., lower pH) in the IVD and these influences were regulated by the IGF-1 binding reactions. This study indicated the complexity of intradiscal administration of growth factors, which needs to be fully analysed in order to achieve a successful outcome. The new theoretical model developed in this study can serve as a powerful tool in analysing and designing the optimal treatments of growth factors for disc degeneration. |
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Authors:
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C-Y Huang; F Travascio; W Y Gu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-02-25 |
Journal Detail:
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Title: Journal of biomechanics Volume: 45 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-16 Completed Date: 2012-08-09 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 1149-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Stem Cell and Mechanobiology Lab, Dept of Biomedical Engineering, University of Miami, Coral Gables, Florida 33146, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Finite Element Analysis Glucose / metabolism Humans Hydrogen-Ion Concentration Injections Insulin-Like Growth Factor I / administration & dosage*, metabolism, pharmacokinetics Intervertebral Disc / drug effects*, metabolism Intervertebral Disc Degeneration / drug therapy*, metabolism Lactic Acid / biosynthesis Lumbar Vertebrae / drug effects, metabolism Models, Biological Protein Binding Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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AR050609/AR/NIAMS NIH HHS; AR056101/AR/NIAMS NIH HHS; EB008653/EB/NIBIB NIH HHS; R01 AR050609/AR/NIAMS NIH HHS; R01 EB008653/EB/NIBIB NIH HHS; R03 AR056101/AR/NIAMS NIH HHS; R03 AR056101-02/AR/NIAMS NIH HHS; R03 AR056101-03/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 50-99-7/Glucose; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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