Document Detail


Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection.
MedLine Citation:
PMID:  22365501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exogenous administration of IGF-1 has been proposed as a therapy for disc degeneration. The objectives of this study were to develop a numerical model for quantitatively analysing exogenous administration of IGF-1 into the intervertebral disc (IVD) via intradiscal injection and to investigate the effects of IGF-1 administration on distribution of glucose and oxygen in the IVD. In this study, the reversible binding reaction between IGF-1 and IGF binding proteins was incorporated into the mechano-electrochemical mixture model. The model was used to numerically analyse transport of IGF-1, glucose, oxygen and lactate in the IVD after IGF-1 administration. The enhancement of IGF-1 on lactate production was also taken into account in the theoretical model. The numerical analyses using finite element method demonstrated that the binding reactions significantly affect the time-dependent distribution of IGF-1 in the IVD. It was found that the region affected by IGF-1 was smaller and the duration of the therapeutic IGF-1 level was longer in the degenerated disc with a higher concentration of IGF binding proteins. It was also found that the IGF-1 injection can reduce glucose concentration and increase lactate accumulation (i.e., lower pH) in the IVD and these influences were regulated by the IGF-1 binding reactions. This study indicated the complexity of intradiscal administration of growth factors, which needs to be fully analysed in order to achieve a successful outcome. The new theoretical model developed in this study can serve as a powerful tool in analysing and designing the optimal treatments of growth factors for disc degeneration.
Authors:
C-Y Huang; F Travascio; W Y Gu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-25
Journal Detail:
Title:  Journal of biomechanics     Volume:  45     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-09     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1149-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Biomechanical Phenomena
Finite Element Analysis
Glucose / metabolism
Humans
Hydrogen-Ion Concentration
Injections
Insulin-Like Growth Factor I / administration & dosage*,  metabolism,  pharmacokinetics
Intervertebral Disc / drug effects*,  metabolism
Intervertebral Disc Degeneration / drug therapy*,  metabolism
Lactic Acid / biosynthesis
Lumbar Vertebrae / drug effects,  metabolism
Models, Biological
Protein Binding
Tissue Distribution
Grant Support
ID/Acronym/Agency:
AR050609/AR/NIAMS NIH HHS; AR056101/AR/NIAMS NIH HHS; EB008653/EB/NIBIB NIH HHS; R01 AR050609/AR/NIAMS NIH HHS; R01 EB008653/EB/NIBIB NIH HHS; R03 AR056101/AR/NIAMS NIH HHS; R03 AR056101-02/AR/NIAMS NIH HHS; R03 AR056101-03/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
33X04XA5AT/Lactic Acid; 67763-96-6/Insulin-Like Growth Factor I; IY9XDZ35W2/Glucose
Comments/Corrections

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