Document Detail

Quantitative analysis of dobutamine-atropine stress echocardiography by fractional area change.
MedLine Citation:
PMID:  12144842     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the usefulness of fractional area change with respect to the diagnosis of coronary artery disease in patients undergoing dobutamine-atropine stress echocardiography. METHODS AND RESULTS: Sixty-eight echogenic patients with a normal left ventricular function referred for coronary angiography underwent dobutamine-atropine stress echocardiography. Measures of fractional area change by segments and by total left ventricular areas were normalized using data from 27 echogenic healthy subjects. The area under the receiver operator characteristics curve indicated a significant diagnostic contribution of fractional area change for both methods (P<0.05) and sensitivity and specificity for predicting significant coronary stenosis were 80% (95% CI 69-91%) and 76% (95% CI 56-97%) for fractional area change of the total left ventricular area of the two chamber view, comparable to results of conventional wall motion analysis. Segmental fractional area change offered no advantages to that of total left ventricular areas with regard to the diagnosis or localization of coronary artery disease. CONCLUSION: Fractional area change of the total left ventricular area is an accurate marker of coronary artery disease and may form a basis for quantitative dobutamine-atropine stress echocardiography analysis provided that reproducible endocardial tracings can be obtained.
S Carstensen; U Høst; K Saunamäki; H Kelbaek
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  3     ISSN:  1525-2167     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-11-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
Department of Medicine B, The Heart Center at Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Denmark.
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage,  diagnostic use*
Anti-Arrhythmia Agents / administration & dosage,  diagnostic use*
Atropine / administration & dosage,  diagnostic use*
Blood Pressure / drug effects
Coronary Artery Disease / diagnosis,  physiopathology
Dobutamine / administration & dosage,  diagnostic use*
Dose-Response Relationship, Drug
Echocardiography, Stress*
Heart Rate / drug effects
Heart Ventricles / ultrasonography
Infusions, Intravenous
Middle Aged
Predictive Value of Tests
Reference Values
Sensitivity and Specificity
Stroke Volume / drug effects,  physiology
Ventricular Function
Ventricular Function, Left / drug effects,  physiology
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Anti-Arrhythmia Agents; 34368-04-2/Dobutamine; 51-55-8/Atropine

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