| Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication. | |
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MedLine Citation:
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PMID: 12731653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hair and plasma from patients on long-term selegiline medication were analyzed to evaluate the relationships between plasma and hair melanin concentrations and the incorporation of the selegiline metabolites methamphetamine and amphetamine in hair, and to evaluate hair analyses for determining compliance in medication. Analyses were performed on both the whole hairs, as well as pigmented and non-pigmented hairs from gray-haired patients. Melanin was quantitated by spectrophotometry, and metabolites were quantitated by gas chromatography-mass spectrometry. Concentrations in pigmented and non-pigmented hairs differed significantly for both methamphetamine (p < 0.01) and amphetamine (p < 0.02), with mean concentration ratios being 3.69 +/- 1.88 and 2.95 +/- 1.16 for methamphetamine and amphetamine, respectively. Segmental analysis indicated that some patients had not been compliant with medication. We concluded that the incorporation of methamphetamine and amphetamine into hair of single individuals shows a preference for pigmented hairs over white hairs and that segmental analysis of hair may be useful when measuring compliance with medication. |
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Authors:
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Robert Kronstrand; Johan Ahlner; Nil Dizdar; Göran Larson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 27 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-06 Completed Date: 2004-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 135-41 Citation Subset: IM |
Affiliation:
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National Board of Forensic Medicine, Department of Forensic Chemistry, Linköping University Hospital, SE-581 85 Linköping, Sweden. robert.kronstrand@rmv.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amphetamine / analysis, blood Amphetamines / analysis*, blood Antiparkinson Agents / administration & dosage, metabolism* Drug Administration Schedule Female Hair / chemistry*, metabolism Hair Color / drug effects Humans Male Melanins / analysis Methamphetamine / analysis, blood Middle Aged Parkinson Disease / drug therapy, metabolism* Patient Compliance Selegiline / administration & dosage, metabolism* Spectrophotometry |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 0/Antiparkinson Agents; 0/Melanins; 14611-51-9/Selegiline; 18913-84-3/desmethylselegiline; 300-62-9/Amphetamine; 537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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