Document Detail


Quantitative analysis of changes occurring in muscle vastus lateralis in patients with heart failure after low-intensity training.
MedLine Citation:
PMID:  10560519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To quantitate the changes occurring in muscle vastus lateralis after exercise training of low intensity adopted for the rehabilitation of patients with chronic heart failure.
STUDY DESIGN: Nine consecutive males with a clinical diagnosis of idiopathic dilated and ischemic cardiomyopathy underwent an eight-week period of training. The intensity of the work was calculated as 40% of peak VO2. The program consisted of 30 minutes of cycling three times per week. A cardiopulmonary exercise test, hemodynamic measurements and echocardiographic studies were carried out. Needle biopsies were taken from muscle vastus lateralis before starting and after completing training. Quantitative analysis was carried out on sections stained with ATPase at pH 9.5 for measurement of the lesser diameter of type 1 and 2 fibers (by using an image analyzer) and on UEA 1-stained sections for capillary density and capillary/fiber ratio (by using a frame in the eyepiece of the microscope). The Wilcoxon test was applied to identify significant differences before and after training. Spearman's rank correlation coefficient was also calculated to highlight any correlation between the morphologic data and results of clinical tests.
RESULTS: After completing the training program, all the patients experienced an improvement in exercise tolerance and a significant increase (P < .004) in the VO2 and VCO2 peak. Skeletal muscle showed a significant (P < .02) increase in the capillary/fiber ratio. The changes were not significantly correlated with any of the clinical findings.
CONCLUSION: Low-intensity training can improve the functional capacity of patients with heart failure while producing only mild morphologic changes in their muscles.
Authors:
M Scarpelli; R Belardinelli; D Tulli; L Provinciali
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology     Volume:  21     ISSN:  0884-6812     ISO Abbreviation:  Anal. Quant. Cytol. Histol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8506819     Medline TA:  Anal Quant Cytol Histol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Capillaries / pathology
Cardiomyopathy, Dilated / physiopathology,  rehabilitation*,  ultrasonography
Chronic Disease
Echocardiography
Exercise Test
Exercise Therapy*
Hemodynamics / physiology
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Muscle Fibers, Skeletal / pathology
Muscle, Skeletal / blood supply,  physiopathology*
Myocardial Ischemia / physiopathology,  rehabilitation*,  ultrasonography
Oxygen Consumption

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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