Document Detail


Quantitative analysis of asbestos burden in women with mesothelioma.
MedLine Citation:
PMID:  12541274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Lung tissue from 15 women who died from mesothelioma was evaluated for tissue burden of ferruginous bodies and uncoated asbestos fibers. The group contained individuals who had occupational exposure to asbestos and others had family members whose work history included vocations where contact with asbestos containing materials occurred. METHODS: Tissue samples from tumor free lung were digested and filtered and then investigated for ferruginous bodies by light microscopy and asbestos and non-asbestos fibers by analytical transmission electron microscopy (ATEM). Size and type of fibers were also analyzed. RESULTS: Asbestos bodies were found in 13 of the 15 samples and asbestos fibers were found in all cases. The most commonly found uncoated asbestos fiber in these individuals was amosite whereas tremolite was the second most commonly found form. The asbestos fiber burden in these females was often of mixed types. CONCLUSIONS: The asbestos body and fiber burden in these cases show variation in tissue burden. Some cases in this study had appreciable burden, which was attributed to secondhand exposure from occupationally exposed family members. Mesothelioma can occur also in individuals with comparatively low tissue burdens of asbestos.
Authors:
Ronald F Dodson; Michael O'Sullivan; Dwaina R Brooks; Samuel P Hammar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  43     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-05-22     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA. ronald.dodson@uthct.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Asbestos, Amosite / adverse effects,  analysis*
Asbestos, Amphibole / adverse effects,  analysis*
Asbestos, Crocidolite / adverse effects,  analysis*
Asbestosis / etiology,  pathology
Body Burden
Environmental Exposure / adverse effects
Female
Humans
Lung / pathology
Lung Neoplasms / etiology,  pathology*
Mesothelioma / etiology,  pathology*
Microscopy, Electron
Middle Aged
Mineral Fibers / adverse effects,  analysis
Occupational Exposure / adverse effects
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Asbestos, Amphibole; 0/Mineral Fibers; 12001-28-4/Asbestos, Crocidolite; 12172-73-5/Asbestos, Amosite; 14567-73-8/tremolite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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