| Quantitative analysis of 99Tcm-sestamibi myocardial perfusion SPECT using a three-dimensional reference heart: a comparison with experienced observers. | |
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MedLine Citation:
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PMID: 11258402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Quantification of myocardial perfusion single photon emission computed tomography (SPECT) may improve scintigraphic analysis. Recently, a fully operator independent technique for the quantification of myocardial perfusion SPECT was described, based on a normal three-dimensional averaged reference heart. The purpose of this study was to compare the automated SPECT quantification technique with experienced observers. METHODS: A total of 43 patients, 36 with one-vessel coronary artery disease (CAD) and seven with a low likelihood of CAD, underwent 99Tcm-sestamibi SPECT (99Tcm-MIBI SPECT). Three experienced observers and a panel (composed of the three observers), blinded to the clinical and angiographic data, analysed the size and severity of perfusion defects and the relation to the distribution areas of the coronary arteries. Inter-observer agreement was calculated by using kappa (kappa) statistics. RESULTS: The inter-observer agreement between the human observers and the automated quantitative analysis, for severity and size of perfusion abnormality, was moderate (kappa range 0.38-0.68), while this was fair between three individual observers (kappa range 0.36-0.87) and good between the individual observers and the panel (kappa range 0.63-0.89). There were no differences between the quantitative analysis and the panel in the allocation of perfusion abnormalities to the affected coronary artery. CONCLUSIONS: The operator independent quantification method showed a moderate agreement with individual observers and a panel analysis for size and severity of perfusion abnormalities. The automatic quantification has a similar ability to assign perfusion abnormalities to the diseased coronary artery as compared to an expert panel. |
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Authors:
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H J Verberne; J B Habraken; E A van Royen; M M Tiel- van Buul; J J Piek; B L van Eck-Smit; H J Verbeme |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 22 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-21 Completed Date: 2001-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 155-63 Citation Subset: IM |
Affiliation:
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Departments of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands. h.j.verberne@amc.uva.nl [corrected]. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Coronary Circulation / physiology* Coronary Disease / radionuclide imaging Coronary Vessels / radionuclide imaging Female Heart / radionuclide imaging* Humans Image Processing, Computer-Assisted Male Middle Aged Observer Variation Radiopharmaceuticals / diagnostic use* Reference Values Technetium Tc 99m Sestamibi / diagnostic use* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
| Comments/Corrections | |
Erratum In:
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Nucl Med Commun 2001 May;22(5):605 Note: Verbeme HJ [corrected to Verberne HJ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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