Document Detail

Quantitative analysis of 99Tcm-sestamibi myocardial perfusion SPECT using a three-dimensional reference heart: a comparison with experienced observers.
MedLine Citation:
PMID:  11258402     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Quantification of myocardial perfusion single photon emission computed tomography (SPECT) may improve scintigraphic analysis. Recently, a fully operator independent technique for the quantification of myocardial perfusion SPECT was described, based on a normal three-dimensional averaged reference heart. The purpose of this study was to compare the automated SPECT quantification technique with experienced observers. METHODS: A total of 43 patients, 36 with one-vessel coronary artery disease (CAD) and seven with a low likelihood of CAD, underwent 99Tcm-sestamibi SPECT (99Tcm-MIBI SPECT). Three experienced observers and a panel (composed of the three observers), blinded to the clinical and angiographic data, analysed the size and severity of perfusion defects and the relation to the distribution areas of the coronary arteries. Inter-observer agreement was calculated by using kappa (kappa) statistics. RESULTS: The inter-observer agreement between the human observers and the automated quantitative analysis, for severity and size of perfusion abnormality, was moderate (kappa range 0.38-0.68), while this was fair between three individual observers (kappa range 0.36-0.87) and good between the individual observers and the panel (kappa range 0.63-0.89). There were no differences between the quantitative analysis and the panel in the allocation of perfusion abnormalities to the affected coronary artery. CONCLUSIONS: The operator independent quantification method showed a moderate agreement with individual observers and a panel analysis for size and severity of perfusion abnormalities. The automatic quantification has a similar ability to assign perfusion abnormalities to the diseased coronary artery as compared to an expert panel.
H J Verberne; J B Habraken; E A van Royen; M M Tiel- van Buul; J J Piek; B L van Eck-Smit; H J Verbeme
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  22     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Departments of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands. [corrected].
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MeSH Terms
Coronary Circulation / physiology*
Coronary Disease / radionuclide imaging
Coronary Vessels / radionuclide imaging
Heart / radionuclide imaging*
Image Processing, Computer-Assisted
Middle Aged
Observer Variation
Radiopharmaceuticals / diagnostic use*
Reference Values
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi
Erratum In:
Nucl Med Commun 2001 May;22(5):605
Note: Verbeme HJ [corrected to Verberne HJ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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