Document Detail

Quantitative analysis of 8-hydroxyguanine in peripheral blood cells: an application for asbestosis patients.
MedLine Citation:
PMID:  8406929     Owner:  NLM     Status:  MEDLINE    
The quantitative analysis of 8-hydroxy-2'-deoxyguanosine (oh8dG) in human peripheral blood cells was carried out to find integrated biomarkers for estimating cancer risk. The change of the oh8dG levels over time in two healthy volunteers was measured to evaluate a intraindividual variance and each individual value was confirmed to be almost constant when they maintained usual life style. We applied this measurement to asbestosis patients who had worked in dockyard for 19-42 years. The oh8dG were detected in all samples and ranged from 0.77 to 1.28/10(5) deoxyguanosine (dG)8. No significant differences was observed in mean values of oh8dG between patients (1.00 +/- 0.17/10(5)dG) and hospital control group without asbestos exposure (1.03 +/- 0.20/10(5)dG) No association was found with the status of cigarette smoking. The oh8dG level in peripheral blood cells is therefore not a sensitive biomarker for past asbestos exposure at low levels.
T Hanaoka; S Tsugane; Y Yamano; T Takahashi; H Kasai; Y Natori; S Watanabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  65     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-26     Completed Date:  1993-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S215-7     Citation Subset:  IM    
Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan.
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MeSH Terms
Asbestosis / blood*
Biological Markers / blood*
Case-Control Studies
DNA Damage
Environmental Monitoring
Guanine / analogs & derivatives*,  blood
Leukocytes / chemistry
Occupational Exposure / analysis
Reg. No./Substance:
0/Biological Markers; 5614-64-2/8-hydroxyguanine; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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