Document Detail


Quantitative account of propranolol metabolism in urine of normal man.
MedLine Citation:
PMID:  2859169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent study, identifying several sulfate conjugates, appears to have led to a full qualitative account of propranolol metabolism in man. The objective of the present investigation was to determine the quantitative fate of propranolol, including the relationship between the primary metabolic pathways, i.e. glucuronidation, side-chain oxidation and ring oxidation. Single 80-mg oral doses of propranolol together with [3H]propranolol were administered to seven normal subjects. Urinary metabolites were determined by HPLC with radiometric detection after hydrolysis of glucuronic acid conjugates and fractionation by solvent extraction. About 90% of the dose was recovered in urine. Twelve metabolites accounted for 91% of the recovered dose. When examining the metabolites based on the primary metabolic pathways, 17% of the dose (range, 10-25%) was going through glucuronidation, 41% (range, 32-50%) through side-chain oxidation, and 42% (range, 27-59%) through ring oxidation. These data show that the net elimination of propranolol is largely due to oxidative metabolism. The relative contribution of the primary pathways is well reflected by the four major propranolol metabolites, i.e. propranolol glucuronide, naphthoxylactic acid, and the glucuronic acid and sulfate conjugates of 4'-hydroxypropranolol. These observations should greatly facilitate future studies of the biochemical mechanisms of propranolol disposition.
Authors:
T Walle; U K Walle; L S Olanoff
Related Documents :
7370309 - The metabolic fate of 14c-labeled peptidoglycan monomer in mice. i. identification of t...
3411439 - Metabolism of diltiazem. i. structures of new acidic and basic metabolites in rat, dog ...
22859649 - Quality, stability and radical scavenging activity of olive oils after chetoui olives (...
3874599 - Purification and characterization of epidermal growth factor (beta-urogastrone) and epi...
10744179 - Analysis of urinary s-phenylmercapturic acid and trans, trans-muconic acid as exposure ...
6499809 - Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood an...
15244409 - Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing boc...
1955159 - Alkaline reflux oesophagitis.
11090249 - Keloids in rural black south africans. part 1: general overview and essential fatty aci...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  13     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-06-19     Completed Date:  1985-06-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chromatography, High Pressure Liquid
Glucuronates / biosynthesis
Humans
Male
Oxidation-Reduction
Propranolol / metabolism,  urine*
Grant Support
ID/Acronym/Agency:
HL 29566/HL/NHLBI NIH HHS; RR 01070/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glucuronates; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polyamine effects on cytochrome P-450- and flavin-containing monooxygenase-mediated oxidation of xen...
Next Document:  Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper ...