Document Detail


Quantitative and semiquantitative measures of regional pulmonary microvascular perfusion by magnetic resonance imaging and their relationships to global lung perfusion and lung diffusing capacity: the multiethnic study of atherosclerosis chronic obstructive pulmonary disease study.
MedLine Citation:
PMID:  23385398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to evaluate the quantitative and semiquantitative measures of regional pulmonary parenchymal perfusion in patients with chronic obstructive pulmonary disease (COPD) in relationship to global lung perfusion (GLP) and lung diffusing capacity (DLCO).
MATERIALS AND METHODS: A total of 143 participants in the Multiethnic Study of Atherosclerosis COPD Study were examined by dynamic contrast-enhanced pulmonary perfusion magnetic resonance imaging (MRI) at 1.5 T. Pulmonary microvascular blood flow (PBF) was calculated on a pixel-by-pixel basis by using a dual-bolus technique and the Fermi function model. Semiquantitative parameters for regional pulmonary microvascular perfusion were calculated from signal intensity-time curves in the lung parenchyma. Intraoberserver and interobserver coefficients of variation (CVs) and correlations between quantitative and semiquantitative MRI parameters and with GLP and DLCO were determined.
RESULTS: Quantitative and semiquantitative parameters of pulmonary microvascular perfusion were reproducible, with CVs for all parameters of less than 10%. Furthermore, these MRI parameters were correlated with GLP and DLCO, and there was good agreement between PBF and GLP. Quantitative and semiquantitative MRI parameters were closely correlated (eg, r = 0.86 for maximum signal increase with PBF). In participants without COPD, the physiological distribution of pulmonary perfusion could be determined by regional MRI measurements.
CONCLUSION: Regional pulmonary microvascular perfusion can reliably be quantified from dynamic contrast-enhanced MRI. Magnetic resonance imaging-derived quantitative and semiquantitative perfusion measures correlate with GLP and DLCO.
Authors:
Katja Hueper; Megha A Parikh; Martin R Prince; Christian Schoenfeld; Chia Liu; David A Bluemke; Stephen M Dashnaw; Thomas A Goldstein; Eric A Hoffman; Joao A Lima; Jan Skrok; Jie Zheng; R Graham Barr; Jens Vogel-Claussen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Investigative radiology     Volume:  48     ISSN:  1536-0210     ISO Abbreviation:  Invest Radiol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-08-23     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Flow Velocity
Case-Control Studies
Contrast Media / diagnostic use
Female
Gadolinium DTPA / diagnostic use
Humans
Magnetic Resonance Imaging / methods
Male
Microcirculation
Middle Aged
Prospective Studies
Pulmonary Circulation*
Pulmonary Disease, Chronic Obstructive / pathology*,  physiopathology*
Respiratory Function Tests
Grant Support
ID/Acronym/Agency:
N01-HC95159-HC95169/HC/NHLBI NIH HHS; P30 ES005605/ES/NIEHS NIH HHS; R01 HL075476/HL/NHLBI NIH HHS; R01 HL077612/HL/NHLBI NIH HHS; R01 HL093081/HL/NHLBI NIH HHS; R01-HL075476/HL/NHLBI NIH HHS; R01-HL077612/HL/NHLBI NIH HHS; R01-HL093081/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; K2I13DR72L/Gadolinium DTPA
Comments/Corrections

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