Document Detail


Quantitative Proteomics of the Human Skin Secretome reveal a Reduction of Immune Defense Mediators in Ectodermal Dysplasia Patients.
MedLine Citation:
PMID:  25347115     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In healthy human skin host defense molecules such as antimicrobial peptides (AMPs) contribute to skin immune homeostasis. In patients with the congenital disease ectodermal dysplasia (ED) skin integrity is disturbed and as a result patients have recurrent skin infections. The disease is characterized by developmental abnormalities of ectodermal derivatives and absent or reduced sweating. We hypothesized that ED patients have a reduced skin immune defense due to the reduced ability to sweat. Therefore, we performed a label-free quantitative proteome analysis of wash solution of human skin from ED patients or healthy individuals. A clear cut difference between both cohorts could be observed in cellular processes related to immunity and host defense. In line with the extensive underrepresentation of proteins of the immune system, dermcidin, a sweat derived AMP, was reduced in its abundance in the skin secretome of ED patients. In contrast, proteins involved in metabolic/catabolic- and biosynthetic processes were enriched in the skin secretome of ED patients. In summary, our proteome profiling provides insights into the actual situation of healthy versus diseased skin. The systematic reduction of immune system and defense related proteins may contribute to the high susceptibility of ED patients to skin infections and altered skin colonization.Journal of Investigative Dermatology accepted article preview online, 27 October 2014. doi:10.1038/jid.2014.462.
Authors:
Marc Burian; Ana Velic; Katarina Matic; Stephanie Günther; Beatrice Kraft; Lena Gonser; Stephan Forchhammer; Yvonne Tiffert; Christian Naumer; Michael Krohn; Mark Berneburg; Amir S Yazdi; Boris Maček; Birgit Schittek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-27
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  -     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-27     Completed Date:  -     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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