| Quantitative Measures of Modic Changes in Lumbar Spine MRI: Intra- and Inter-rater Reliability. | |
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MedLine Citation:
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PMID: 21217445 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Study Design. A measurement reliability study.Objective. To develop quantitative measures for Modic changes (MCs) on magnetic resonance (MR) images and evaluate measurement reliability.Summary of Backaground Data. MCs have been studied for over 20 years but the clinical significance remains controversial. Little effort has been made to improve the measurement of MCs.Materials and Methods. The study was approved by the responsible institutional review board. Based on Modic classification, a series of quantitative dimension and signal intensity measures were developed for assessing MCs. Mid-sagittal T1 and T2-weighted MR images from 83 lumbar spines were then qualitatively and quantitatively assessed by two observers independently. Kappa and intra-class correlation coefficient (ICC) were used to examine intra- and inter-rater reliability. Pearson correlation coefficient was used to assess the relationships between the quantitative measurements of MCs. Mean absolute deviation (MAD) and Bland-Altman Plots also were used to evaluate measurement errors and limits of agreement for selected measures.Results. For Modic classification, intra-rater agreement was excellent (κ = 0.88) and inter-rater agreement was substantial (κ = 0.79). Intra-rater agreement also was excellent when obtaining dimension measurements (ICC = 0.82 to 0.96) from T1 or T2-weighted images and inter-rater agreement was slightly greater using T1-weighted images (ICC = 0.73 to 0.88) than T2-weighted images (ICC = 0.66 to 0.82). Signal intensity measurements on T2-weighted images were found to have almost perfect intra- and inter-rater reliability (ICC = 0.92 to 0.99). The correlation analysis demonstrated that the quantitative measures represent different constructs. The MAD and Bland-Altman Plots further confirmed the high reliability of the area ratio, MCs mean signal intensity and MCs total signal intensity measurements.Conclusions. Three quantitative measures are suggested to assess the severity of MCs, which provide reliable, precise measurements for research on the etiology, pathogenesis and clinical relevance of MCs. |
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Authors:
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Yue Wang; Tapio Videman; Riikka Niemeläinen; Michele C Battié |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-6 |
Journal Detail:
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Title: Spine Volume: - ISSN: 1528-1159 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Rehabilitation Medicine, 3-48 Corbett Hall, University of Alberta, Edmonton, AB, Canada T6G 2G4, Tel: 1 780 492 1610, Fax: 1 780 492 1626. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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