Document Detail


Quantitative MRI of spinal cord injury in a rat model.
MedLine Citation:
PMID:  7997114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sequential in vivo MRI studies of experimental spinal cord injuries (SCI) were performed using a three-dimensional implementation of the FATE (Fast low-Angle spin echo sequence with short TE) sequence. MRI-observed pathology was quantified using a multispectral segmentation algorithm. Neurological analysis was performed on the same animals concurrently, in addition to end-point histology, for comparison with quantitative MRI results. These studies suggest that it is possible to use MRI to detect the onset of secondary injury in the spinal cord. The data also indicate that early detection of MRI-visible pathology may provide the necessary markers for predicting the long-term level of neurologic deficit.
Authors:
J C Falconer; P A Narayana; M B Bhattacharjee; S J Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  32     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-01-19     Completed Date:  1995-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-91     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Texas Medical School at Houston 77030.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging / methods*
Male
Neurologic Examination
Rats
Rats, Sprague-Dawley
Spinal Cord / pathology
Spinal Cord Injuries / diagnosis*,  pathology
Time Factors
Grant Support
ID/Acronym/Agency:
R01 NS30821/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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