Document Detail


Quantitative MR imaging in Alzheimer disease.
MedLine Citation:
PMID:  16990669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer disease (AD) is the most common type of dementia. It currently affects approximately 4 million people in the United States. AD is a progressive neurodegenerative disorder characterized by the gradual deposition of neuritic plaques and neurofibrillary tangles in the brain, which is thought to occur decades before the onset of clinical symptoms. Identification of people at risk before the clinical appearance of dementia has become a priority due to the potential benefits of therapeutic intervention. Although atrophy of medial temporal lobe structures has been shown to correlate with progression of AD, a growing number of recent reports have indicated that such atrophy may not be specific to AD. To improve diagnostic specificity, new quantitative magnetic resonance (MR) imaging methods are being developed that exploit known pathogenic mechanisms exclusive to AD. This article reviews the MR techniques that are currently available for the diagnostic assessment of AD.
Authors:
Anita Ramani; Jens H Jensen; Joseph A Helpern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Radiology     Volume:  241     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-44     Citation Subset:  AIM; IM    
Copyright Information:
(c) RSNA, 2006.
Affiliation:
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016-3240, USA. anita.raman@med.nyu.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / diagnosis*
Humans
Magnetic Resonance Imaging / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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