Document Detail

Quantitative effects of coil packing density on cerebral aneurysm fluid dynamics: an in vitro steady flow study.
MedLine Citation:
PMID:  20306135     Owner:  NLM     Status:  MEDLINE    
Over the past 15 years, coil embolization has emerged as an effective treatment option for cerebral aneurysms that is far less invasive than the long-standing convention of surgical clipping. However, aneurysm recurrence after coil embolization is not uncommon: recurrence rates as high as 50% have been reported in the literature. One factor that may contribute to recurrence after coiling is residual flow into the aneurysmal sac. At present, there is limited quantitative knowledge of the relationship between coil packing density and aneurysmal inflow. We present an in vitro fluid dynamic study of basilar tip aneurysm models that elucidates this relationship. At physiologically normal flow rates, we found that a packing density of 28.4% decreased aneurysmal inflow by 31.6% in a wide-neck model, and that a packing density of 36.5% decreased aneurysmal inflow by 49.6% in a narrow-neck model. Results also indicated that coiling reduced aneurysmal inflow more significantly at lower parent vessel flow rates, and that coiling reduced neck-plane velocity magnitudes more significantly for narrow-neck aneurysms. Our study provides novel quantitative information that could ultimately contribute to improved outcomes for patients with cerebral aneurysms by enabling more effective coil embolization.
M Haithem Babiker; L Fernando Gonzalez; Felipe Albuquerque; Daniel Collins; Arius Elvikis; David H Frakes
Related Documents :
20966055 - Stent-assisted coiling of complex middle cerebral artery aneurysms: initial and midterm...
19057425 - Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline emboliza...
18759575 - Wingspan stent system in the endovascular treatment of intracranial aneurysms: clinical...
16293065 - Development of medical devices for neuro-interventional procedures: special focus on an...
15546295 - Carotid artery stenting: state of the art.
996175 - The site of reapplication of microvascular clamps.
Publication Detail:
Type:  Journal Article     Date:  2010-03-20
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-09-10     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2293-301     Citation Subset:  IM    
School of Biological and Health Systems Engineering, Arizona State University, 501 E. Tyler, Tempe, AZ 85287-9709, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aneurysm / etiology,  radiography,  therapy
Blood Vessel Prosthesis
Intracranial Aneurysm* / radiography,  surgery,  therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The lamellar spacing in self-assembling bacteriochlorophyll aggregates is proportional to the length...
Next Document:  Limitation of finite element analysis of poroelastic behavior of biological tissues undergoing rapid...