Document Detail


Quantitative effects of coil packing density on cerebral aneurysm fluid dynamics: an in vitro steady flow study.
MedLine Citation:
PMID:  20306135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past 15 years, coil embolization has emerged as an effective treatment option for cerebral aneurysms that is far less invasive than the long-standing convention of surgical clipping. However, aneurysm recurrence after coil embolization is not uncommon: recurrence rates as high as 50% have been reported in the literature. One factor that may contribute to recurrence after coiling is residual flow into the aneurysmal sac. At present, there is limited quantitative knowledge of the relationship between coil packing density and aneurysmal inflow. We present an in vitro fluid dynamic study of basilar tip aneurysm models that elucidates this relationship. At physiologically normal flow rates, we found that a packing density of 28.4% decreased aneurysmal inflow by 31.6% in a wide-neck model, and that a packing density of 36.5% decreased aneurysmal inflow by 49.6% in a narrow-neck model. Results also indicated that coiling reduced aneurysmal inflow more significantly at lower parent vessel flow rates, and that coiling reduced neck-plane velocity magnitudes more significantly for narrow-neck aneurysms. Our study provides novel quantitative information that could ultimately contribute to improved outcomes for patients with cerebral aneurysms by enabling more effective coil embolization.
Authors:
M Haithem Babiker; L Fernando Gonzalez; Felipe Albuquerque; Daniel Collins; Arius Elvikis; David H Frakes
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Publication Detail:
Type:  Journal Article     Date:  2010-03-20
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-09-10     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2293-301     Citation Subset:  IM    
Affiliation:
School of Biological and Health Systems Engineering, Arizona State University, 501 E. Tyler, Tempe, AZ 85287-9709, USA. haithem.babiker@asu.edu
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MeSH Terms
Descriptor/Qualifier:
Aneurysm / etiology,  radiography,  therapy
Blood Vessel Prosthesis
Humans
Intracranial Aneurysm* / radiography,  surgery,  therapy
Recurrence
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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