Document Detail


Quantitative EEG and effect of hypothermia on brain recovery after cardiac arrest.
MedLine Citation:
PMID:  16761828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper, we provide a quantitative electroencephalogram (EEG) analysis to study the effect of hypothermia on the neurological recovery of brain after cardiac arrest. We hypothesize that the brain injury results in a reduction in information of the brain rhythm. To measure the information content of the EEG a new measure called information quantity (IQ), which is the Shannon entropy of decorrelated EEG signals, is developed. For decorrelating EEG signals, we use the discrete wavelet transform (DWT) which is known to have good decorrelating properties and to show a good match to the standard clinical bands in EEG. In measuring the amount of information, IQ shows better tracking capability for dynamic amplitude change and frequency component change than conventional entropy-based measures. Experiments are carried out in rodents (n = 30) to monitor the neurological recovery after cardiac arrest. In addition, EEG signal recovery under normothermic (37 degrees C) and hypothermic (33 degrees C) resuscitation following 5, 7, and 9 min of cardiac arrest is recorded and analyzed. Experimental results show that the IQ is greater for hypothermic than normothermic rats, with an IQ difference of more than 0.20 (0.20 +/- 0.11 is 95% condidence interval). The results quantitatively support the hypothesis that hypothermia accelerates the electrical recovery from brain injury after cardiac arrest.
Authors:
Hyun-Chool Shin; Shanbao Tong; Soichiro Yamashita; Xiaofeng Jia; Romergryko G Geocadin; Nitish V Thakor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  53     ISSN:  0018-9294     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-07-07     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1016-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Coma / etiology,  physiopathology*,  prevention & control*
Diagnosis, Computer-Assisted / methods*
Electroencephalography / methods*
Heart Arrest / complications,  physiopathology*,  therapy
Hypothermia, Induced / methods*
Rats
Rats, Wistar
Recovery of Function / physiology
Therapy, Computer-Assisted / methods*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HL71568/HL/NHLBI NIH HHS; NS42640/NS/NINDS NIH HHS; R01 HL071568/HL/NHLBI NIH HHS; R01 HL071568-03/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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