Document Detail


Quantitative ColourDopplerSonography evaluation of cerebral venous outflow: a comparative study between patients with multiple sclerosis and controls.
MedLine Citation:
PMID:  21966398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Internal Jugular Veins (IJVs) are the principle outflow pathway for intracranial blood in clinostatism condition. In the seated position, IJVs collapse, while Vertebral Veins (VVs) increase the venous outflow and partially compensate the venous drainage. Spinal Epidural Veins are an additional drainage pathway in the seated position. Colour- Doppler-Sonography (CDS) examination is able to demonstrate IJVs and VVs outflow in different postural and respiratory conditions. The purpose of this study was to evaluate CDS quantification of the cerebral venous outflow (CVF) in healthy subjects and patients with multiple sclerosis (MS).
METHODOLOGY/PRINCIPAL FINDINGS: In a group of 27 healthy adults (13 females and 14 males; mean age 37.8 ± 11.2 years), and 52 patients with MS (32 females and 20 males; mean age 42.6 ± 12.1 years), CVF has been measured in clinostatism and in the seated position as the sum of the flow in IJVs and VVs. The difference between CVF in clinostatism and CVF in the seated position (ΔCVF) has been correlated with patients' status (healthy or MS), and a number of clinical variables in MS patients. Statistical analysis was performed by Fisher's exact test, non-parametric Mann-Whitney U test, ANOVA Kruskal-Wallis test, and correntropy coefficient. The value of ΔCVF was negative in 59.6% of patients with MS and positive in 96.3% of healthy subjects. Negative ΔCVF values were significantly associated with MS (p<0.0001). There was no significant correlation with clinical variables.
CONCLUSIONS/SIGNIFICANCE: Negative ΔCVF has a hemodynamic significance, since it reflects an increased venous return in the seated position. This seems to be a pathologic condition. In MS patients, a vascular dysregulation resulting from involvement of the autonomous nervous system may be supposed. ΔCVF value should be included in the quantitative CDS evaluation of the cerebral venous drainage, in order to identify cerebral venous return abnormalities.
Authors:
Lucia Monti; Elisabetta Menci; Monica Ulivelli; Alfonso Cerase; Sabina Bartalini; Pietro Piu; Nicola Marotti; Sara Leonini; Paolo Galluzzi; Daniele G Romano; Alfredo E Casasco; Carlo Venturi
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Publication Detail:
Type:  Journal Article     Date:  2011-09-22
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-06-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e25012     Citation Subset:  IM    
Affiliation:
Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy. l.monti@ao-siena.toscana.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cerebral Veins / ultrasonography*
Cerebrovascular Circulation / physiology
Color
Female
Hemodynamics
Humans
Male
Middle Aged
Multiple Sclerosis / physiopathology,  ultrasonography*
Regional Blood Flow
Ultrasonography, Doppler / methods*
Venous Insufficiency / ultrasonography
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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