| Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation. | |
| | |
MedLine Citation:
|
PMID: 19796970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morphological alteration of small pulmonary vessels and the extent of emphysema has not been assessed in vivo. The objectives of this study are: to evaluate the correlation of total cross-sectional area (CSA) of small pulmonary vessels with the extent of emphysema and airflow obstruction using CT scans and to assess the difference of total CSA between COPD phenotypes. MATERIALS AND METHODS: We measured CSA less than 5 mm(2) and 5-10 mm(2), and calculated the percentage of the total CSA for the lung area (%CSA < 5, and %CSA5-10, respectively) using CT scans in 191 subjects. The extent of emphysema (%LAA-950) was calculated, and the correlations of %CSA < 5 and %CSA5-10 with %LAA-950 and results of pulmonary function tests (PFTs) were evaluated. The differences in %CSA between COPD phenotypes were also assessed. RESULTS: The %CSA < 5 had significant negative correlations with %LAA-950 (r = -0.83, P < .0001). There was a weak but statistically significant correlation of %CSA < 5 with forced expiratory volume in 1 second (FEV1)% predicted (r = 0.29, P < .0001) and FEV1/forced vital capacity (r = 0.45, P < .0001). A %CSA 5-10 had weak correlations with %LAA-950 and results of PFTs. %CSA < 5 was significantly higher in bronchitis phenotype than in the emphysema phenotype (P < .0001). CONCLUSIONS: Total CSA of small pulmonary vessels at sub-subsegmental levels strongly correlates with the extent of emphysema (%LAA-950) and reflects differences between COPD phenotypes. |
| | |
Authors:
|
Shin Matsuoka; George R Washko; Mark T Dransfield; Tsuneo Yamashiro; Raul San Jose Estepar; Alejandro Diaz; Edwin K Silverman; Samuel Patz; Hiroto Hatabu |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-09-30 |
Journal Detail:
|
Title: Academic radiology Volume: 17 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-08 Completed Date: 2010-02-24 Revised Date: 2012-06-12 |
Medline Journal Info:
|
Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 93-9 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. shin4114@mac.com |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00047385 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Comorbidity Emphysema / epidemiology*, radiography* Female Humans Incidence Male Massachusetts / epidemiology Middle Aged Pulmonary Artery / radiography* Pulmonary Disease, Chronic Obstructive / epidemiology*, radiography* Radiographic Image Interpretation, Computer-Assisted / methods* Risk Assessment / methods Risk Factors Statistics as Topic Tomography, X-Ray Computed / statistics & numerical data* |
| Grant Support | |
ID/Acronym/Agency:
|
1K23HL089353-01A1/HL/NHLBI NIH HHS; K23 HL089353/HL/NHLBI NIH HHS; K23 HL089353-01A1/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transforming growth factor beta 1 as a biomarker of diabetic peripheral neuropathy: cross-sectional ...
Next Document: Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine...