Document Detail


Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.
MedLine Citation:
PMID:  19796970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morphological alteration of small pulmonary vessels and the extent of emphysema has not been assessed in vivo. The objectives of this study are: to evaluate the correlation of total cross-sectional area (CSA) of small pulmonary vessels with the extent of emphysema and airflow obstruction using CT scans and to assess the difference of total CSA between COPD phenotypes.
MATERIALS AND METHODS: We measured CSA less than 5 mm(2) and 5-10 mm(2), and calculated the percentage of the total CSA for the lung area (%CSA < 5, and %CSA5-10, respectively) using CT scans in 191 subjects. The extent of emphysema (%LAA-950) was calculated, and the correlations of %CSA < 5 and %CSA5-10 with %LAA-950 and results of pulmonary function tests (PFTs) were evaluated. The differences in %CSA between COPD phenotypes were also assessed.
RESULTS: The %CSA < 5 had significant negative correlations with %LAA-950 (r = -0.83, P < .0001). There was a weak but statistically significant correlation of %CSA < 5 with forced expiratory volume in 1 second (FEV1)% predicted (r = 0.29, P < .0001) and FEV1/forced vital capacity (r = 0.45, P < .0001). A %CSA 5-10 had weak correlations with %LAA-950 and results of PFTs. %CSA < 5 was significantly higher in bronchitis phenotype than in the emphysema phenotype (P < .0001).
CONCLUSIONS: Total CSA of small pulmonary vessels at sub-subsegmental levels strongly correlates with the extent of emphysema (%LAA-950) and reflects differences between COPD phenotypes.
Authors:
Shin Matsuoka; George R Washko; Mark T Dransfield; Tsuneo Yamashiro; Raul San Jose Estepar; Alejandro Diaz; Edwin K Silverman; Samuel Patz; Hiroto Hatabu
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-09-30
Journal Detail:
Title:  Academic radiology     Volume:  17     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-08     Completed Date:  2010-02-24     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. shin4114@mac.com
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00047385
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MeSH Terms
Descriptor/Qualifier:
Aged
Comorbidity
Emphysema / epidemiology*,  radiography*
Female
Humans
Incidence
Male
Massachusetts / epidemiology
Middle Aged
Pulmonary Artery / radiography*
Pulmonary Disease, Chronic Obstructive / epidemiology*,  radiography*
Radiographic Image Interpretation, Computer-Assisted / methods*
Risk Assessment / methods
Risk Factors
Statistics as Topic
Tomography, X-Ray Computed / statistics & numerical data*
Grant Support
ID/Acronym/Agency:
1K23HL089353-01A1/HL/NHLBI NIH HHS; K23 HL089353/HL/NHLBI NIH HHS; K23 HL089353-01A1/HL/NHLBI NIH HHS
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