| Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 20651191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to evaluate the relation between bronchial wall attenuation on thin-section CT images and airflow limitation in persons with chronic obstructive pulmonary disease. SUBJECTS AND METHODS: One hundred fourteen subjects (65 men, 49 women; age range, 56-74 years) enrolled in the National Lung Screening Trial underwent chest CT and prebronchodilation spirometry at a single institution. At CT, mean peak wall attenuation, wall area percentage, and luminal area were measured in the third, fourth, and fifth generations of the right B(1) and B(10) segmental bronchi. Correlations with forced expiratory volume in the first second of expiration (FEV(1)) expressed as percentage of predicted value were evaluated with Spearman's rank correlation test. RESULTS: The peak wall attenuation of each generation of segmental bronchi correlated significantly with FEV(1) as percentage of predicted value (B(1) third, r = -0.323, p = 0.0005; B(1) fourth, r = -0.406, p < 0.0001; B(1) fifth, r = -0.478, p < 0.0001; B(10) third, r = -0.268, p = 0.004; B(10) fourth, r = -0.476, p < 0.0001; B(10) fifth, r = -0.548, p < 0.0001). The correlation coefficients were higher in peripheral airway generations. Wall area percentage and luminal area had similar significant correlations. In multivariate analysis to predict FEV(1) as percentage of predicted value, the coefficient of determination of the model with the combination of percentage of low-attenuation area (< -950 HU) and peak wall attenuation of the fifth generation of the right B(10) was 0.484; the coefficient of determination with percentage of low-attenuation area and wall area percentage was 0.40. CONCLUSION: Peak attenuation of the bronchial wall measured at CT correlates significantly with expiratory airflow obstruction in subjects with chronic obstructive pulmonary disease, particularly in the distal airways. |
| | |
Authors:
|
Tsuneo Yamashiro; Shin Matsuoka; Raúl San José Estépar; Mark T Dransfield; Alejandro Diaz; John J Reilly; Samuel Patz; Sadayuki Murayama; Edwin K Silverman; Hiroto Hatabu; George R Washko |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: AJR. American journal of roentgenology Volume: 195 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
|
Languages: eng Pagination: 363-9 Citation Subset: AIM; IM |
Affiliation:
|
Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston, MA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Algorithms* Bronchography / methods* Female Humans Male Middle Aged Pulmonary Disease, Chronic Obstructive / radiography* Radiographic Image Interpretation, Computer-Assisted / methods* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Grant Support | |
ID/Acronym/Agency:
|
1K23HL089353-01A1/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of Stress Perfusion MRI and SPECT for Detection of Myocardial Ischemia in Patients With A...
Next Document: Incremental Value of PET/CT Over CT for Mediastinal Nodal Staging of Non-Small Cell Lung Cancer: Com...