Document Detail


Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI.
MedLine Citation:
PMID:  20440567     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: This study describes a quantitative method to estimate the migratory capacity of neural stem cells (NSCs) using magnetic resonance imaging.
PROCEDURES: NSCs were labeled with ferumoxides and injected stereotaxically into the corpus callosum of the normal rat brain. Control subjects received either free ferumoxides or nonviable labeled cells. Subjects were scanned after initial injection and at 1 week. Image sets were coregistered, compared morphologically, and analyzed parametrically to determine migration speed.
RESULTS: Subjects receiving injections of viable cells had a significantly greater spread of the tracer after 1 week than either control group (p < 0.05). The speed of migration for viable NSCs was significantly higher than that of controls along the corpus callosum (p < 0.05). Migratory speeds estimated from histology and imaging were significantly correlated.
CONCLUSIONS: This study provides a quantitative assessment of posttransplantation neural stem cell migration that is clearly distinguishable from tracer clearance.
Authors:
Jennifer A Flexman; Donna J Cross; Linh N Tran; Takahiro Sasaki; Yongmin Kim; Satoshi Minoshima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging     Volume:  13     ISSN:  1860-2002     ISO Abbreviation:  Mol Imaging Biol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125610     Medline TA:  Mol Imaging Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-11     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, University of Washington, 1705 N.E. Pacific Street, Box 355061, Seattle, WA, 98195-5061, USA.
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