Document Detail


Quantitative analysis of bulk flow in image-based hemodynamic models of the carotid bifurcation: the influence of outflow conditions as test case.
MedLine Citation:
PMID:  20589532     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although flow-driven mechanisms associated with vascular physiopathology also deal with four-dimensional phenomena such as species transport, the majority of the research on the subject focuses primarily on wall shear stress as indicator of disturbed flow. Indeed, the role that bulk flow plays in vascular physiopathology has not been thoroughly investigated, partly because of a lack of descriptors that would be able to reduce the intricacy of arterial hemodynamics. Here, an approach is proposed to investigate, in silico, the bulk flow within the carotid bifurcation. For this purpose, we coupled a three-dimensional model of carotid bifurcation with a lumped model of the downstream vasculature. For the sake of comparison, we also imposed three different fixed flow rate repartitions between the internal and external carotid arteries on the three-dimensional model. The bulk flow was characterized by applying a descriptor of helical motion, the helical flow index (HFI) to the model; the HFI has recently been shown to provide an accurate representation of complex flows. Moreover, a new metric is presented to investigate the vorticity dynamics within the bifurcation. Our results highlight the effectiveness of these metrics in the following contexts: (i) identifying and ranking emerging hemodynamic features and (ii) quantifying the influence of the outflow boundary conditions on the composition of the translational and rotational components of the fluid motion. The metrics applied herein allow for a more comprehensive analysis, which may lead to the development of an instrument to relate the bulk flow to vascular pathophysiological events that involve not only fluid-related forces, but also transport phenomena within blood.
Authors:
Umberto Morbiducci; Diego Gallo; Raffaele Ponzini; Diana Massai; Luca Antiga; Franco M Montevecchi; Alberto Redaelli
Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-03-01     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3688-705     Citation Subset:  IM    
Affiliation:
Department of Mechanics, Politecnico di Torino, Turin, Italy. umberto.morbiducci@polito.it
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MeSH Terms
Descriptor/Qualifier:
Biomedical Engineering
Blood Flow Velocity
Carotid Arteries / anatomy & histology,  physiology*
Computer Simulation
Hemodynamics
Hemorheology
Humans
Imaging, Three-Dimensional
Models, Cardiovascular*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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