| Quantitative analysis of bulk flow in image-based hemodynamic models of the carotid bifurcation: the influence of outflow conditions as test case. | |
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MedLine Citation:
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PMID: 20589532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although flow-driven mechanisms associated with vascular physiopathology also deal with four-dimensional phenomena such as species transport, the majority of the research on the subject focuses primarily on wall shear stress as indicator of disturbed flow. Indeed, the role that bulk flow plays in vascular physiopathology has not been thoroughly investigated, partly because of a lack of descriptors that would be able to reduce the intricacy of arterial hemodynamics. Here, an approach is proposed to investigate, in silico, the bulk flow within the carotid bifurcation. For this purpose, we coupled a three-dimensional model of carotid bifurcation with a lumped model of the downstream vasculature. For the sake of comparison, we also imposed three different fixed flow rate repartitions between the internal and external carotid arteries on the three-dimensional model. The bulk flow was characterized by applying a descriptor of helical motion, the helical flow index (HFI) to the model; the HFI has recently been shown to provide an accurate representation of complex flows. Moreover, a new metric is presented to investigate the vorticity dynamics within the bifurcation. Our results highlight the effectiveness of these metrics in the following contexts: (i) identifying and ranking emerging hemodynamic features and (ii) quantifying the influence of the outflow boundary conditions on the composition of the translational and rotational components of the fluid motion. The metrics applied herein allow for a more comprehensive analysis, which may lead to the development of an instrument to relate the bulk flow to vascular pathophysiological events that involve not only fluid-related forces, but also transport phenomena within blood. |
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Authors:
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Umberto Morbiducci; Diego Gallo; Raffaele Ponzini; Diana Massai; Luca Antiga; Franco M Montevecchi; Alberto Redaelli |
Publication Detail:
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Type: Journal Article Date: 2010-06-30 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1573-9686 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-03-01 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 3688-705 Citation Subset: IM |
Affiliation:
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Department of Mechanics, Politecnico di Torino, Turin, Italy. umberto.morbiducci@polito.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomedical Engineering Blood Flow Velocity Carotid Arteries / anatomy & histology, physiology* Computer Simulation Hemodynamics Hemorheology Humans Imaging, Three-Dimensional Models, Cardiovascular* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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