| Quantitative 4D Transcatheter Intraarterial Perfusion MRI for Standardizing Angiographic Chemoembolization Endpoints. | |
| | |
MedLine Citation:
|
PMID: 22021520 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to test the hypothesis that subjective angiographic endpoints during transarterial chemoembolization (TACE) of hepatocellular carcinoma are consistent and correlate with objective intraprocedural reductions in tumor perfusion determined with quantitative 4D transcatheter intraarterial perfusion MRI. SUBJECTS AND METHODS: In this prospective study, 18 consecutively registered patients underwent TACE in a combined MRI-interventional radiology suite. Three board-certified interventional radiologists independently graded the angiographic endpoint of each procedure using a previously described subjective angiographic chemoembolization endpoint scale. A consensus endpoint rating was established for each patient. Patients underwent quantitative 4D transcatheter intraarterial perfusion MRI immediately before and after TACE, and mean whole tumor perfusion was calculated from the images. Consistency of subjective angiographic endpoint ratings between observers was evaluated with the intraclass correlation coefficient. The relation between the endpoint ratings and intraprocedural transcatheter intraarterial perfusion MRI changes was evaluated with the Spearman rank correlation coefficient. RESULTS: The subjective angiographic chemoembolization endpoint rating scale showed very good consistency among all observers (intraclass correlation coefficient, 0.80). The consensus endpoint rating correlated significantly with both absolute (r = 0.54, p = 0.022) and percentage (r = 0.85, p < 0.001) reduction in intraprocedural perfusion. CONCLUSION: The subjective angiographic chemoembolization endpoint rating scale shows very good consistency between raters and significantly correlates with objectively measured intraprocedural perfusion reductions during TACE. These results support the use of the scale as a standardized alternative method in quantitative 4D transcatheter intraarterial perfusion MRI to classify patients on the basis of embolic endpoints of TACE. |
| | |
Authors:
|
Brian Jin; Dingxin Wang; Robert J Lewandowski; Robert K Ryu; Kent T Sato; Andrew C Larson; Riad Salem; Reed A Omary |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: AJR. American journal of roentgenology Volume: 197 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
|
Languages: eng Pagination: 1237-43 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, Northwestern University, Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ossification patterns of the atlas vertebra.
Next Document: Pretreatment Imaging Can Be Used to Select Imaging Guidance, Ultrasound Alone Versus CT Plus Ultraso...