| Quantitative (31) P magnetic resonance spectroscopy of the human breast at 7 T. | |
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MedLine Citation:
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PMID: 22213214 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study presents quantified levels of phosphorylated metabolites in glandular tissue of human breast using (31) P magnetic resonance spectroscopy at 7 T. We used a homebuilt (1) H/(31) P radiofrequency coil to obtain artifact-free (31) P MR spectra of glandular tissue of healthy females by deploying whole breast free induction decay (FID) detection with adiabatic excitation and outer volume suppression. Using progressive saturation, the estimated apparent T(1) relaxation time of (31) P spins of phosphocholine and phosphoethanolamine was 4.4 and 5.7 s, respectively. Quantitative measures for phosphocholine and phosphoethanolamine levels in glandular tissue were established based on MR imaging. We used a 3D (1) H image of the breast to segment the glandular tissue; this was matched to a 3D (31) P image of the B 1- field of the (31) P coil to correct for differences in glandular tissue volume and B(1) inhomogeneity of the (31) P coil. The (31) P MR spectra were calibrated using a phantom with known concentration. Average levels of phosphocholine and phosphoethanolamine in 11 volunteers were 0.84 ± 0.21 mM and 1.18 ± 0.41 mM, respectively. In addition, data of three patients with breast cancer showed higher levels of phosphocholine and phosphoethanolamine compared with healthy volunteers. This may indicate a potential role for the use of (31) P magnetic resonance spectroscopy for characterization, prognosis, and treatment monitoring in breast cancer. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Jannie P Wijnen; Wybe J M van der Kemp; Mariska P Luttje; Mies A Korteweg; Peter R Luijten; Dennis W J Klomp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands. jpwijnen@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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