Document Detail

Quantitative 2- and 3-dimensional analysis of pharmacokinetic model-derived variables for breast lesions in dynamic, contrast-enhanced MR mammography.
MedLine Citation:
PMID:  17658235     Owner:  NLM     Status:  MEDLINE    
PURPOSE: 2- and 3-dimensional evaluation of quantitative pharmacokinetic parameters derived from the Tofts model modeling dynamic contrast enhancement of lesions in MR mammography. MATERIALS AND METHODS: In 95 patients, MR mammography revealed 127 suspicious lesions. The initial rate of enhancement was coded by color intensity, the post-initial enhancement change is coded by color hue. 2D and 3D analysis of distribution of color hue and intensity, vascular permeability and extracellular volume were performed. RESULTS: In 2D, malignant lesions showed significant higher number of bright red, medium red, dark red, bright green, medium green, dark green and bright blue pixels than benign lesions. In 3D, statistical significant differences between malignant and benign lesions was found for all this parameters. Vascular permeability was significant higher in malignant lesions than in benign lesions. Regression model using the 3D data found that the best discriminator between malignant and benign lesions was combined number of voxels and medium green pixels, with a sensitivity of 79.4% and a specificity of 83.1%. CONCLUSIONS: Quantitative analysis of pharmacokinetic variables of contrast kinetics showed significant differences between malignant and benign lesions. 3D analysis showed superior diagnostic differentiation between malignant and benign lesions than 2D analysis. The parametric analysis using a pharmacokinetic model allows objective analysis of contrast enhancement in breast lesions.
E A M Hauth; H J Jaeger; S Maderwald; A Muehler; R Kimmig; M Forsting
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Publication Detail:
Type:  Journal Article     Date:  2007-07-19
Journal Detail:
Title:  European journal of radiology     Volume:  66     ISSN:  0720-048X     ISO Abbreviation:  Eur J Radiol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  300-8     Citation Subset:  IM    
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D-45122 Essen, Germany.
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MeSH Terms
Breast Diseases / diagnosis*
Chi-Square Distribution
Contrast Media / pharmacokinetics*
Diagnosis, Differential
Gadolinium DTPA / pharmacokinetics*
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Logistic Models
Magnetic Resonance Imaging / methods*
Middle Aged
ROC Curve
Regression Analysis
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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