| Quantitation of normal metabolite concentrations in six brain regions by in-vivoH-MR spectroscopy. | |
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MedLine Citation:
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PMID: 20927223 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study examined the concentrations of brain metabolites visible to in-vivo(1)H-Magnetic Resonance Spectroscopy ((1)H-MRS) at 1.5 T in a sample of 28 normal subjects. Quantitation was attempted for inositol compounds, choline units, total creatine and N-acetyl moieties, using open-source software. Six brain regions were considered: frontal and parietal white matter, medial temporal lobe, thalamus, pons and cerebellum. Absolute concentrations were derived using tissue water as an internal reference and using an external reference; metabolite signal intensity ratios with respect to creatine were also calculated. The inter-individual variability was smaller for absolute concentrations (internal reference) as compared to that for signal intensity ratios. Significant regional variability in concentration was found for all metabolites, indicating that separate normative values are needed for different brain regions. The values obtained in this study can be used as reference in future studies, provided the same methodology is followed; it is confirmed that despite unsuccessful attempts in the past, smaller coefficients of variation can indeed be obtained through absolute quantification. |
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Authors:
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Ludovico Minati; Domenico Aquino; Maria Grazia Bruzzone; Alessandra Erbetta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical physics / Association of Medical Physicists of India Volume: 35 ISSN: 1998-3913 ISO Abbreviation: J Med Phys Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-10-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441104 Medline TA: J Med Phys Country: India |
Other Details:
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Languages: eng Pagination: 154-63 Citation Subset: - |
Affiliation:
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Scientific Department Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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