Document Detail


Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine.
MedLine Citation:
PMID:  17996357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial remodeling determines the degree of left ventricular dysfunction and mortality after transmural chronic myocardial infarction (CMI). Noninvasive characterization and quantitation of myocardial borderzone and collagenous scar are therefore parameters of clinical interest. The aims of this study were (i) to measure accuracy of reconstructive 3-D echocardiography (3DE) in scar and myocardial borderzone size assessment and (ii) to investigate the incremental value of low-dose dobutamine stress. 3DE was performed in 14 immunodeficient rats (rnu-rnu, 180-200 g) with anterior CMI 25 d after coronary ligation. Briefly, consecutive parallel short-axis cineloops were obtained electrocardiogram-gated starting from base to the apex. Morphology (mass, surface) and function (contractility, contractile reserve) of different compartments were assessed and correlated with 3-D histomorphometry. Histology was done using picrosirius red for collagen staining. 3DE left ventricular mass correlated closely with histomorphometry (y = 0.89x + 155, p < 0.0001, r = 0.80). Hypo- and akinetic myocardial surface correlated well with borderzone myocardium (y = 0.34x + 17, p = 0.009, r = 0.62) and collagenous scar (y = 1.9x + 4.4, p < 0.0001, r = 0.79), respectively. Extent of abnormal wall motion was closely related to borderzone and scar tissue area (y = 0.82x + 7, p < 0.0001, r = 0.77). 3DE quantitation of borderzone myocardium, but not collagenous scar, was more closely correlated to histomorphometry during inotropic stimulation. Global contractile reserve is positively associated with the size of myocardial borderzone. Regional contractile reserve of borderzone myocardium is not negatively associated with its collagen content. 3DE allows precise quantitation of myocardial borderzone and identification of transmural scar tissue noninvasively. Assessment of contractile reserve improves characterization and estimation of myocardial borderzone after CMI.
Authors:
Alexander Ghanem; Clemens Troatz; Naziha Elhafi; Oliver Dewald; Christopher Heeschen; Georg Nickenig; Joerg Stypmann; Klaus Tiemann
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-08
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  34     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  559-66     Citation Subset:  IM    
Affiliation:
Department of Medicine/Cardiology, University of Bonn, Bonn, Germany. ghanem@uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / administration & dosage,  diagnostic use*
Cicatrix / pathology,  ultrasonography
Disease Models, Animal
Dobutamine / administration & dosage,  diagnostic use*
Feasibility Studies
Female
Image Processing, Computer-Assisted / methods
Imaging, Three-Dimensional / methods
Myocardial Contraction
Myocardial Infarction / pathology,  physiopathology,  ultrasonography*
Rats
Rats, Nude
Ventricular Remodeling
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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