Document Detail


Quantitation and localization of cellular retinol-binding protein in squamous-cell carcinomas of the cervix uteri and of the oral cavity.
MedLine Citation:
PMID:  3366495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of cellular retinol-binding protein (CRBP) was determined by radioimmunoassay in biopsies of normal mucosa and squamous-cell carcinomas of cervix uteri from 30 women. The tumour tissues contained significantly higher concentrations of CRBP (median = 120 micrograms/g protein) than normal mucosa (median = 32 micrograms/g protein). The distribution of CRBP in normal mucosa and squamous-cell carcinomas from cervix uteri and from oral cavity was evaluated by immunohistochemical techniques. In tissue sections of normal epithelium from the cervix uteri and the oral cavity, the maturing keratinocytes in the prickle-cell layers were moderately or strongly stained when antiserum against CRBP was used, while the proliferating cells in the basal-cell layer were stained only lightly if at all. Squamous-cell carcinomas of the cervix uteri and the oral cavity presented much the same picture. The observed difference in CRBP concentration between squamous-cell carcinomas and normal squamous-cell mucosa may therefore be more quantitative than qualitative.
Authors:
P Wahlberg; G Fex; A Biörklund; C Tropé; R Willén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  41     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-20     Completed Date:  1988-06-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  771-6     Citation Subset:  IM    
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / analysis*
Cervix Mucus / analysis
Female
Humans
Immunohistochemistry
Middle Aged
Mouth Mucosa / analysis
Mouth Neoplasms / analysis*
Radioimmunoassay
Retinol-Binding Proteins / analysis*
Retinol-Binding Proteins, Cellular
Uterine Cervical Neoplasms / analysis*
Chemical
Reg. No./Substance:
0/Retinol-Binding Proteins; 0/Retinol-Binding Proteins, Cellular

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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