Document Detail

Quantitation of left ventricular asynchrony on radionuclide angiography phase images.
MedLine Citation:
PMID:  2209649     Owner:  NLM     Status:  MEDLINE    
Quantitation of left ventricular (LV) asynchrony is relevant in clinical cardiology, as well as in evaluating LV mechanical properties. Radionuclide angiography (RA) phase images are extensively used, and asynchrony is usually assessed by computing the standard deviation of phase angle distribution (SD). However, SD is dependent on count statistics and does not take into account the spatial distribution of asynchrony. In this study a new index to evaluate asynchrony on phase images is presented (differential uniformity parameter, DUP). DUP is based on the frequency analysis of phase images. Diagnostic accuracy and reproducibility of either SD or DUP were tested. Reproducibility was evaluated in 15 patients studied by RA twice within a few minutes. DUP showed a better reproducibility than SD. Diagnostic accuracy was estimated in 84 patients, divided into four subgroups on the basis of coronary arteriography and contrast ventriculography findings: (a) 25 control subjects, (b) 16 patients with coronary artery disease (CAD) and normal LV wall motion, (c) 23 patients with CAD and LV hypokinesia and (d) 20 patients with CAD and LV dyskinesia. Relative diagnostic ability was assessed by comparing the areas under receiver-operating characteristic curves. DUP's area was larger than SD's when group D was tested against all the other groups (DUP's area = 87% +/- 5%, SD's area = 76% +/- 7%; P less than 0.01). Thus, our study indicates that DUP is more reproducible and more accurate than SD in identifying patients with CAD and LV dyskinesia.
B Alfano; S Betocchi; L Pace; P Perrone-Filardi; M Chiariello; M Salvatore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  16     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-11-13     Completed Date:  1990-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  801-6     Citation Subset:  IM    
Department of Radiology-Nuclear Medicine, University of Naples 2nd School of Medicine, Italy.
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MeSH Terms
Coronary Disease / radionuclide imaging*
Gated Blood-Pool Imaging / methods*
Middle Aged
ROC Curve
Reproducibility of Results
Ventricular Function, Left / physiology

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