| Quantitation of the information content of multi-dimensional gas chromatography and low-resolution mass spectrometry in the identification of doping drugs. | |
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MedLine Citation:
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PMID: 44879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On the basis of information theory, a comparison of the performance of the identification of compounds by multi-dimensional gas chromatography and binary-encoded low-resolution mass spectrometry is made for doping drugs. This group of compounds was not selected at random but according to their pharmocological effects. For these compounds it was observed that the m/e values of the peaks in the mass spectra are highly correlated, while a number of chromatographic columns can be found on which the retention data are only slightly correlated. As a result, the information content of two-dimensional gas chromatographic retention data on such columns equals the information content of binary-encoded low-resolution mass spectra. It is shown that the accuracy and precision of retention data in gas--liquid chromatography, and therefore the information content, can be significantly improved if the data are corrected for adsorption effects of the solid support and extrapolated to a limiting value in the case of asymmetric peaks. |
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Authors:
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J F Huber; E Kenndler; G Reich |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of chromatography Volume: 172 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1980-09-23 Completed Date: 1980-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 15-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Central Nervous System Stimulants
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analysis* Chromatography, Gas Information Theory Mass Spectrometry Mathematics Phenethylamines / analysis |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 0/Phenethylamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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