| Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy. | |
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MedLine Citation:
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PMID: 2341336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current methods for measuring cerebral blood volume (CBV) in newborn infants are unsatisfactory. A new method is described in which the effect of a small change (5-10%) in arterial oxygen saturation (SaO2) on cerebral oxyhemoglobin [HbO2] and deoxyhemoglobin [Hb] concentration is observed by near-infrared (NIR) spectroscopy. Previous experiments in which the NIR absorption characteristics of HbO2 and Hb and the pathlength of NIR light through the brain were defined allowed changes in [HbO2] and [Hb] to be quantified from the Beer-Lambert law. It is shown here that CBV can then be derived from the expression CBV = (delta[HbO2] - delta[Hb])/(2. delta SaO2.H.R.), where H is the large vessel total hemoglobin concentration and R to the cerebral-to-large vessel hematocrit ratio. Observations on 12 newborn infants with normal brains, born at 25-40 wk of gestation and aged 10-240 h, gave a mean value for CBV of 2.22 +/- 0.40 (SD) ml/100 g, whereas mean CBV was significantly higher 3.00 +/- 1.04 ml/100 g in 10 infants with brain injury born at 24 to 42 wk of gestation and aged 4-168 h (P less than 0.05). |
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Authors:
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J S Wyatt; M Cope; D T Delpy; C E Richardson; A D Edwards; S Wray; E O Reynolds |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 68 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-06-25 Completed Date: 1990-06-25 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1086-91 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University College London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Volume* Brain Injuries / blood, physiopathology Cerebrovascular Circulation* Evaluation Studies as Topic Hemoglobins / metabolism Humans Infant, Newborn Oxyhemoglobins / metabolism Reference Values Spectrophotometry, Infrared / instrumentation, methods* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 9008-02-0/deoxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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