Document Detail


Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.
MedLine Citation:
PMID:  9626067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we sought to learn about when and how amyloid beta-protein (A beta) accumulates in the cortex of normal individuals and about the difference in the A beta accumulation between normal aged and Alzheimer's disease (AD) brains. From consecutive autopsy cases and AD cases, hippocampus CA1 and occipitotemporal cortex T4 were sampled for A beta quantitation by the well characterized two-site enzyme immunoassays (EIAs). There was a strong tendency toward A beta 42 accumulation between the ages of 50 and 70 years in T4 and a little later in CA1. The A beta 42 levels were consistently higher in T4 than those in CA1 in any given case. The levels of A beta 42 in AD brains were significantly higher than those in control brains, and the extent of A beta 42 amino-terminal modification was also much greater in AD brains than that in control brains. Even in cases in which no senile plaques were immunocytochemically detected, EIAs clearly showed that significant amounts of A beta 42 already had accumulated. In contrast to A beta 42, A beta 40 showed no apparent age-dependent accumulation, and its high levels were found to be associated with AD.
Authors:
H Funato; M Yoshimura; K Kusui; A Tamaoka; K Ishikawa; N Ohkoshi; K Namekata; R Okeda; Y Ihara
Related Documents :
14656067 - Neuropathology of cognitively normal elderly.
15121247 - Quantitative ultrasound at hand phalanges in adults with end-stage renal failure.
8460957 - Greater abnormalities of brain cerebrospinal fluid volumes in younger than in older pat...
8544907 - Vip neurons in the human scn in relation to sex, age, and alzheimer's disease.
8385727 - Age changes in visceral content of glutathione in the senescence accelerated mouse (sam).
20126287 - Reproductive partitioning and the assumptions of reproductive skew models in the cooper...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  152     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-07     Completed Date:  1998-07-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1633-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / genetics,  metabolism*
Alzheimer Disease / genetics,  metabolism*
Amyloid beta-Protein / chemistry,  metabolism*
Apolipoproteins E / genetics
Cerebral Cortex / metabolism*
Female
Genotype
Hippocampus / metabolism
Humans
Immunoenzyme Techniques
Immunohistochemistry
Male
Middle Aged
Protein Processing, Post-Translational
Transferrin / genetics
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Apolipoproteins E; 11096-37-0/Transferrin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antigen-dependent progression of mucosa-associated lymphoid tissue (MALT)-type lymphoma in the stoma...
Next Document:  Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and p...