| Quantitation of alpha-factor internalization and response during the Saccharomyces cerevisiae cell cycle. | |
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MedLine Citation:
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PMID: 1656226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alpha-factor pheromone binds to specific cell surface receptors on Saccharomyces cerevisiae a cells. The pheromone is then internalized, and cell surface receptors are down-regulated. At the same time, a signal is transmitted that causes changes in gene expression and cell cycle arrest. We show that the ability of cells to internalize alpha-factor is constant throughout the cell cycle, a cells are also able to respond to pheromone throughout the cycle even though there is cell cycle modulation of the expression of two pheromone-inducible genes, FUS1 and STE2. Both of these genes are expressed less efficiently near or just after the START point of the cell cycle in response to alpha-factor. For STE2, the basal level of expression is modulated in the same manner. |
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Authors:
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B Zanolari; H Riezman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biology Volume: 11 ISSN: 0270-7306 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1991-10-31 Completed Date: 1991-10-31 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5251-8 Citation Subset: IM |
Affiliation:
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Biocenter, University of Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Endocytosis Gene Expression Regulation, Fungal* Genes, Fungal / genetics Kinetics Microscopy, Fluorescence Peptides / metabolism*, pharmacology Receptors, Cell Surface / genetics, metabolism Receptors, Mating Factor Receptors, Peptide* Saccharomyces cerevisiae / cytology, genetics, metabolism* Signal Transduction Transcription Factors* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Receptors, Cell Surface; 0/Receptors, Mating Factor; 0/Receptors, Peptide; 0/Transcription Factors; 61194-02-3/mating factor |
| Comments/Corrections | |
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