Document Detail


Quantitation of HBF gamma-chain types by HPLC in patients with myelodysplastic syndrome.
MedLine Citation:
PMID:  1724440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemoglobinopathies was excluded. The fetal hemoglobin percentage was quantitated by alkali denaturation of the hemolysate, and the gamma chain content was determined in blood hemolysate by HPLC following HbF isolation. A 7/3 ratio of fetal Gy/Ay was found in three patients. Since the survival of MDS patients with high HbF levels was longer than that of patients with low levels of HbF, this finding may be used as a potential prognostic factor.
Authors:
K L Bourantas; I Georgiou; K Seferiadis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haematologica     Volume:  76     ISSN:  0390-6078     ISO Abbreviation:  Haematologica     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1992-04-07     Completed Date:  1992-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  337-8     Citation Subset:  IM    
Affiliation:
Internal Medicine Clinic, Ioannina General Hospital, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine / analysis
Chromatography, High Pressure Liquid*
Female
Fetal Hemoglobin / analysis*
Globins / analysis*
Glycine / analysis
Humans
Male
Middle Aged
Myelodysplastic Syndromes / blood*,  mortality
Prognosis
Chemical
Reg. No./Substance:
56-40-6/Glycine; 56-41-7/Alanine; 9004-22-2/Globins; 9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Flow cytometry to estimate circulating hematopoietic progenitors for autologous transplantation: com...
Next Document:  Immunohistochemical findings of epiretinal membranes after silicone oil injection