Document Detail

Quantifying sympathetic nerve activity: problems, pitfalls and the need for standardization.
MedLine Citation:
PMID:  19700515     Owner:  NLM     Status:  MEDLINE    
Since the first recording of sympathetic nerve activity (SNA) early last century, numerous methods for presentation of the resulting data have developed. In this paper, we discuss the common ways of describing SNA and their application to chronic recordings. Suggestions on assessing the quality of SNA are made, including the use of arterial pressure wave-triggered averages and nasopharyngeal stimuli. Calculation of the zero level of the SNA signal from recordings during ganglionic blockade, the average level between bursts and the minimum of arterial pressure wave-triggered averages are compared and shown to be equivalent. The use of normalization between zero and maximal SNA levels to allow comparison between groups is discussed. We recommend that measured microvolt levels of integrated SNA be presented (with the zero/noise level subtracted), along with burst amplitude and frequency information whenever possible. We propose that standardization of the quantifying/reporting of SNA will allow better comparison between disease models and between research groups and ultimately allow data to be more reflective of the human situation.
Sarah-Jane Guild; Carolyn J Barrett; Fiona D McBryde; Bruce N Van Vliet; Geoffrey A Head; Sandra L Burke; Simon C Malpas
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-08-21
Journal Detail:
Title:  Experimental physiology     Volume:  95     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  IM    
Circulatory Control Laboratory, Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
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MeSH Terms
Action Potentials / physiology
Afferent Pathways / physiology
Blood Pressure / physiology
Kidney / innervation,  physiology
Laboratory Techniques and Procedures / standards
Problem Solving
Reference Standards
Sympathetic Nervous System / physiology*

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