| Quantifying sympathetic nerve activity: problems, pitfalls and the need for standardization. | |
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MedLine Citation:
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PMID: 19700515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the first recording of sympathetic nerve activity (SNA) early last century, numerous methods for presentation of the resulting data have developed. In this paper, we discuss the common ways of describing SNA and their application to chronic recordings. Suggestions on assessing the quality of SNA are made, including the use of arterial pressure wave-triggered averages and nasopharyngeal stimuli. Calculation of the zero level of the SNA signal from recordings during ganglionic blockade, the average level between bursts and the minimum of arterial pressure wave-triggered averages are compared and shown to be equivalent. The use of normalization between zero and maximal SNA levels to allow comparison between groups is discussed. We recommend that measured microvolt levels of integrated SNA be presented (with the zero/noise level subtracted), along with burst amplitude and frequency information whenever possible. We propose that standardization of the quantifying/reporting of SNA will allow better comparison between disease models and between research groups and ultimately allow data to be more reflective of the human situation. |
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Authors:
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Sarah-Jane Guild; Carolyn J Barrett; Fiona D McBryde; Bruce N Van Vliet; Geoffrey A Head; Sandra L Burke; Simon C Malpas |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-08-21 |
Journal Detail:
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Title: Experimental physiology Volume: 95 ISSN: 1469-445X ISO Abbreviation: Exp. Physiol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-12 Completed Date: 2010-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 41-50 Citation Subset: IM |
Affiliation:
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Circulatory Control Laboratory, Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. s.guild@auckland.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Afferent Pathways / physiology Animals Blood Pressure / physiology Humans Kidney / innervation, physiology Laboratory Techniques and Procedures / standards Problem Solving Reference Standards Sympathetic Nervous System / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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