Document Detail


Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction.
MedLine Citation:
PMID:  22732325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Airway hyper-responsiveness (AHR), a hallmark of asthma, is a highly complex phenomenon characterised by multiple processes manifesting over a large range of length and time scales. Multiscale computational models have been derived to embody the experimental understanding of AHR. While current models differ in their derivation, a common assumption is that the increase in parenchymal tethering pressure P(teth) during airway constriction can be described using the model proposed by Lai-Fook (1979), which is based on intact lung experimental data for elastic moduli over a range of inflation pressures. Here we reexamine this relationship for consistency with a nonlinear elastic material law that has been parameterised to the pressure-volume behaviour of the intact lung. We show that the nonlinear law and Lai-Fook's relationship are consistent for small constrictions, but diverge when the constriction becomes large.
Authors:
Barbara J Breen; Graham M Donovan; James Sneyd; Merryn H Tawhai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-23
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  183     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-31     Completed Date:  2013-01-04     Revised Date:  2013-08-19    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Auckland Bioengineering Institute, University of Auckland, Private Bag 92019 Auckland Mail Centre, Auckland 1142, New Zealand. b.breen@auckland.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Asthma / physiopathology
Bronchoconstriction / physiology*
Computer Simulation*
Elasticity / physiology
Finite Element Analysis*
Humans
Lung / physiopathology*
Models, Biological*
Grant Support
ID/Acronym/Agency:
HL103405/HL/NHLBI NIH HHS; R01 HL103405/HL/NHLBI NIH HHS
Comments/Corrections

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